Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia
Abstract Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation. Results In the present cross-sectional descriptive study...
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-019-4319-8 |
| _version_ | 1819076429705379840 |
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| author | Ameen Abdulaziz Basabaeen Enaam Abdelrhman Abdelgader Othman Saeed BaHashwan Ebtihal Ahmed Babekir Nour Mahmoud Abdelateif Salem Ahmed Bamusa Saadia Osman Abdelrahim Osama Ali Altayeb Eman Abbass Fadul Ibrahim Khider Ibrahim |
| author_facet | Ameen Abdulaziz Basabaeen Enaam Abdelrhman Abdelgader Othman Saeed BaHashwan Ebtihal Ahmed Babekir Nour Mahmoud Abdelateif Salem Ahmed Bamusa Saadia Osman Abdelrahim Osama Ali Altayeb Eman Abbass Fadul Ibrahim Khider Ibrahim |
| author_sort | Ameen Abdulaziz Basabaeen |
| collection | DOAJ |
| description | Abstract Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation. Results In the present cross-sectional descriptive study, analysis of ZAP-70 expression showed that 36/110 (32.7%) patients positively expressed ZAP-70 and insignificant higher presentation in intermediate and at advanced stages as well as no correlation was seen with hematological parameters and clinical features compared with negatively ZAP-70, on the other hand, 41/110 (37.3%) were CD38+ and no significant correlation was shown with the stage at presentation, clinical characteristics (except Splenomegaly, P = 0.02) and hematological parameters. However, in combined expressions of both ZAP-70 and CD38 together, 20/110 (18.2%) were concordantly ZAP-70+/CD38+, 53/110 (48.2%) concordantly ZAP-70−/CD38− and 37/110 (33.6%) either ZAP-70+ or CD38+, and these three groups showed insignificant correlation with clinical (except Splenomegaly, P = 0.03) and hematological parameters, and the stage at presentation. Our data showed the combined analysis of these two markers, lead to classify our patients into three subgroups (either concordant positive, negative or discordant expressions) with statistically insignificant correlation with clinical presentation (except Splenomegaly), hematological parameters and stage at presentation of B-CLL patients. |
| first_indexed | 2024-12-21T18:41:10Z |
| format | Article |
| id | doaj.art-aecf7a82840548a6b64515d040bb1f5d |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-21T18:41:10Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-aecf7a82840548a6b64515d040bb1f5d2022-12-21T18:54:01ZengBMCBMC Research Notes1756-05002019-05-011211610.1186/s13104-019-4319-8Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemiaAmeen Abdulaziz Basabaeen0Enaam Abdelrhman Abdelgader1Othman Saeed BaHashwan2Ebtihal Ahmed Babekir3Nour Mahmoud Abdelateif4Salem Ahmed Bamusa5Saadia Osman Abdelrahim6Osama Ali Altayeb7Eman Abbass Fadul8Ibrahim Khider Ibrahim9Department of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain UniversityDepartment of Pathology, Faculty of Medicine, Al Neelain UniversityDepartment of Family Medicine, Faculty of Medicine, University of GeziraDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain UniversityDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain UniversityMinistry of Health & PopulationDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain UniversityFlow Cytometry Laboratory for Leukemia & Lymphoma DiagnosisFlow Cytometry Laboratory for Leukemia & Lymphoma DiagnosisDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain UniversityAbstract Objective To investigate the ZAP-70 and CD38 expressions and their combined expressions in Sudanese B-CLL patients and their relationships with clinical and hematological characteristics as well as the disease staging at presentation. Results In the present cross-sectional descriptive study, analysis of ZAP-70 expression showed that 36/110 (32.7%) patients positively expressed ZAP-70 and insignificant higher presentation in intermediate and at advanced stages as well as no correlation was seen with hematological parameters and clinical features compared with negatively ZAP-70, on the other hand, 41/110 (37.3%) were CD38+ and no significant correlation was shown with the stage at presentation, clinical characteristics (except Splenomegaly, P = 0.02) and hematological parameters. However, in combined expressions of both ZAP-70 and CD38 together, 20/110 (18.2%) were concordantly ZAP-70+/CD38+, 53/110 (48.2%) concordantly ZAP-70−/CD38− and 37/110 (33.6%) either ZAP-70+ or CD38+, and these three groups showed insignificant correlation with clinical (except Splenomegaly, P = 0.03) and hematological parameters, and the stage at presentation. Our data showed the combined analysis of these two markers, lead to classify our patients into three subgroups (either concordant positive, negative or discordant expressions) with statistically insignificant correlation with clinical presentation (except Splenomegaly), hematological parameters and stage at presentation of B-CLL patients.http://link.springer.com/article/10.1186/s13104-019-4319-8B-CLLZAP-70CD38CombinedRaiBinet |
| spellingShingle | Ameen Abdulaziz Basabaeen Enaam Abdelrhman Abdelgader Othman Saeed BaHashwan Ebtihal Ahmed Babekir Nour Mahmoud Abdelateif Salem Ahmed Bamusa Saadia Osman Abdelrahim Osama Ali Altayeb Eman Abbass Fadul Ibrahim Khider Ibrahim Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia BMC Research Notes B-CLL ZAP-70 CD38 Combined Rai Binet |
| title | Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia |
| title_full | Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia |
| title_fullStr | Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia |
| title_full_unstemmed | Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia |
| title_short | Combined analysis of ZAP-70 and CD38 expression in sudanese patients with B-cell chronic lymphocytic leukemia |
| title_sort | combined analysis of zap 70 and cd38 expression in sudanese patients with b cell chronic lymphocytic leukemia |
| topic | B-CLL ZAP-70 CD38 Combined Rai Binet |
| url | http://link.springer.com/article/10.1186/s13104-019-4319-8 |
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