Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver Disease
Aims: To explore the value of preoperative liver function tests (LFTs) for the prognosis of cardiac surgery patients without liver disease.Methods: The Medical Information Mart for Intensive Care III (MIMIC-III) database was used to extract the clinical data. Adult cardiac patients (≥18 years) witho...
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| Format: | Article |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.772430/full |
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| author | Liqun Shang Liqun Shang Yuanhan Ao Yuanhan Ao Linhua Lv Linhua Lv Lihua Lv Yubi Zhang Jian Hou Jian Hou Jianping Yao Jianping Yao Zhongkai Wu Zhongkai Wu |
| author_facet | Liqun Shang Liqun Shang Yuanhan Ao Yuanhan Ao Linhua Lv Linhua Lv Lihua Lv Yubi Zhang Jian Hou Jian Hou Jianping Yao Jianping Yao Zhongkai Wu Zhongkai Wu |
| author_sort | Liqun Shang |
| collection | DOAJ |
| description | Aims: To explore the value of preoperative liver function tests (LFTs) for the prognosis of cardiac surgery patients without liver disease.Methods: The Medical Information Mart for Intensive Care III (MIMIC-III) database was used to extract the clinical data. Adult cardiac patients (≥18 years) without liver disease in the database were enrolled. The association of LFTs with the time of hospital stay and ICU stay was analyzed with the Spearman correlation. Survival curves were estimated using the Kaplan-Meier method and compared by the log-rank test. Multivariable logistic regression was used to identify LFTs that were independent prognostic factors of mortality.Results: A total of 2,565 patients were enrolled in this study. Albumin (ALB) was negatively associated with the time of hospital stay and ICU stay, while alanine transaminase (ALT), aspartate aminotransferase (AST), and total bilirubin were positively associated with the time of hospital stay and ICU stay (all p < 0.001). Abnormal ALB, ALT, AST, and total bilirubin were associated with lower 90-day and 4-year survival (all p < 0.001) and could be used as independent risk factors for hospital mortality and 90-day mortality. However, only ALB and total bilirubin were independent risk factors for 4-year mortality.Conclusion: Preoperative LFT abnormalities were associated with short-term and long-term prognosis of cardiac surgery patients without liver disease. |
| first_indexed | 2024-04-11T20:07:24Z |
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| id | doaj.art-aed02a53b6b2469eaa32981159edc1c6 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T20:07:24Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-aed02a53b6b2469eaa32981159edc1c62022-12-22T04:05:18ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-11-01810.3389/fcvm.2021.772430772430Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver DiseaseLiqun Shang0Liqun Shang1Yuanhan Ao2Yuanhan Ao3Linhua Lv4Linhua Lv5Lihua Lv6Yubi Zhang7Jian Hou8Jian Hou9Jianping Yao10Jianping Yao11Zhongkai Wu12Zhongkai Wu13Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pharmacy, Shaoyang University, Shaoyang, ChinaDepartment of Hematology Oncology, Shaoyang Central Hospital, Shaoyang, ChinaDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou, ChinaAims: To explore the value of preoperative liver function tests (LFTs) for the prognosis of cardiac surgery patients without liver disease.Methods: The Medical Information Mart for Intensive Care III (MIMIC-III) database was used to extract the clinical data. Adult cardiac patients (≥18 years) without liver disease in the database were enrolled. The association of LFTs with the time of hospital stay and ICU stay was analyzed with the Spearman correlation. Survival curves were estimated using the Kaplan-Meier method and compared by the log-rank test. Multivariable logistic regression was used to identify LFTs that were independent prognostic factors of mortality.Results: A total of 2,565 patients were enrolled in this study. Albumin (ALB) was negatively associated with the time of hospital stay and ICU stay, while alanine transaminase (ALT), aspartate aminotransferase (AST), and total bilirubin were positively associated with the time of hospital stay and ICU stay (all p < 0.001). Abnormal ALB, ALT, AST, and total bilirubin were associated with lower 90-day and 4-year survival (all p < 0.001) and could be used as independent risk factors for hospital mortality and 90-day mortality. However, only ALB and total bilirubin were independent risk factors for 4-year mortality.Conclusion: Preoperative LFT abnormalities were associated with short-term and long-term prognosis of cardiac surgery patients without liver disease.https://www.frontiersin.org/articles/10.3389/fcvm.2021.772430/fullpreoperative liver function testscardiac surgeryshort-term prognosislong-term prognosishospital mortality90-day mortality |
| spellingShingle | Liqun Shang Liqun Shang Yuanhan Ao Yuanhan Ao Linhua Lv Linhua Lv Lihua Lv Yubi Zhang Jian Hou Jian Hou Jianping Yao Jianping Yao Zhongkai Wu Zhongkai Wu Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver Disease Frontiers in Cardiovascular Medicine preoperative liver function tests cardiac surgery short-term prognosis long-term prognosis hospital mortality 90-day mortality |
| title | Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver Disease |
| title_full | Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver Disease |
| title_fullStr | Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver Disease |
| title_full_unstemmed | Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver Disease |
| title_short | Preoperative Liver Function Test Abnormalities Were Associated With Short-Term and Long-Term Prognosis in Cardiac Surgery Patients Without Liver Disease |
| title_sort | preoperative liver function test abnormalities were associated with short term and long term prognosis in cardiac surgery patients without liver disease |
| topic | preoperative liver function tests cardiac surgery short-term prognosis long-term prognosis hospital mortality 90-day mortality |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.772430/full |
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