Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs
Background & Objective: Narcissus bulb is an antiphlogistic drug, effective for asthma treatment, shortness of breath and skin burns. The aim of this study was to investigate the effect of Narcissus tazetta bulb extract on serum concentrations of liver function test enzymes (ALT, ALP, AST, LDH,...
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| Format: | Article |
| Language: | English |
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Fasa University of Medical Sciences
2019-11-01
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| Series: | Journal of Advanced Biomedical Sciences |
| Subjects: | |
| Online Access: | http://jabs.fums.ac.ir/article-1-2169-en.pdf |
| _version_ | 1797679576379293696 |
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| author | hassan morovvati nezam armand |
| author_facet | hassan morovvati nezam armand |
| author_sort | hassan morovvati |
| collection | DOAJ |
| description | Background & Objective: Narcissus bulb is an antiphlogistic drug, effective for asthma treatment, shortness of breath and skin burns. The aim of this study was to investigate the effect of Narcissus tazetta bulb extract on serum concentrations of liver function test enzymes (ALT, ALP, AST, LDH, GGT) in male rats.
Materials & Methode: In this study, 20 male rats were divided into 4 groups of 5 series. They were divided into control groups and experimental groups and received the alcoholic extract 50, 100 and 150 mg/kg of Narcissus bulb. The extract was fed for 6 days and blood samples were taken from the animals on the seventh day and serum levels of liver enzymes were measured. Statistical analysis was performed with SPSS software (version 21.0) using t-test.
Results: The activity of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) enzymes in 150 mg/kg extract of Narcissus bulb significantly increased (P<0.01). Also, at the same dose, the enzymes of Alkaline phosphatase (ALP), Lactate Dehydrogenase (LDH) and Gamma Glutamyl Transferase (GGT) showed a significant increase compared to the control group (P<0.05). ALT at 100 - mg/kg dose significantly increased, but AST at 50 mg/kg dose showed a significant decrease compared to the control group (P<0.05).
Conclusion: Considering the significant increase in liver enzymes at high doses of extract, it is necessary to study the histopathological effects of the extracts of this plant on liver. |
| first_indexed | 2024-03-11T23:16:47Z |
| format | Article |
| id | doaj.art-aed1537d6c334e4b8fd2bbb3eab754e6 |
| institution | Directory Open Access Journal |
| issn | 2228-5105 2783-1523 |
| language | English |
| last_indexed | 2024-03-11T23:16:47Z |
| publishDate | 2019-11-01 |
| publisher | Fasa University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Biomedical Sciences |
| spelling | doaj.art-aed1537d6c334e4b8fd2bbb3eab754e62023-09-20T21:26:56ZengFasa University of Medical SciencesJournal of Advanced Biomedical Sciences2228-51052783-15232019-11-019417361742Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbshassan morovvati0nezam armand1 Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran Background & Objective: Narcissus bulb is an antiphlogistic drug, effective for asthma treatment, shortness of breath and skin burns. The aim of this study was to investigate the effect of Narcissus tazetta bulb extract on serum concentrations of liver function test enzymes (ALT, ALP, AST, LDH, GGT) in male rats. Materials & Methode: In this study, 20 male rats were divided into 4 groups of 5 series. They were divided into control groups and experimental groups and received the alcoholic extract 50, 100 and 150 mg/kg of Narcissus bulb. The extract was fed for 6 days and blood samples were taken from the animals on the seventh day and serum levels of liver enzymes were measured. Statistical analysis was performed with SPSS software (version 21.0) using t-test. Results: The activity of Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) enzymes in 150 mg/kg extract of Narcissus bulb significantly increased (P<0.01). Also, at the same dose, the enzymes of Alkaline phosphatase (ALP), Lactate Dehydrogenase (LDH) and Gamma Glutamyl Transferase (GGT) showed a significant increase compared to the control group (P<0.05). ALT at 100 - mg/kg dose significantly increased, but AST at 50 mg/kg dose showed a significant decrease compared to the control group (P<0.05). Conclusion: Considering the significant increase in liver enzymes at high doses of extract, it is necessary to study the histopathological effects of the extracts of this plant on liver.http://jabs.fums.ac.ir/article-1-2169-en.pdfnarcissusratliver enzyme |
| spellingShingle | hassan morovvati nezam armand Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs Journal of Advanced Biomedical Sciences narcissus rat liver enzyme |
| title | Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs |
| title_full | Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs |
| title_fullStr | Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs |
| title_full_unstemmed | Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs |
| title_short | Assessment of Changes in Serum Concentrations of Liver Function (ALT, ALP, AST, LDH, GGT) After the Intake of Narcissus Bulbs |
| title_sort | assessment of changes in serum concentrations of liver function alt alp ast ldh ggt after the intake of narcissus bulbs |
| topic | narcissus rat liver enzyme |
| url | http://jabs.fums.ac.ir/article-1-2169-en.pdf |
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