Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome
This study examines how feeding, sleep, and growth during infancy impact the gut microbiome (GM) in toddlers. The research was conducted on toddlers (<i>n</i> = 36), born to Latina women of low-income with obesity. Their mothers completed retrospective feeding and sleeping questionnaires...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/3/549 |
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| author | Magdalena Olson Samantha Toffoli Kiley B. Vander Wyst Fang Zhou Elizabeth Reifsnider Megan E. Petrov Corrie M. Whisner |
| author_facet | Magdalena Olson Samantha Toffoli Kiley B. Vander Wyst Fang Zhou Elizabeth Reifsnider Megan E. Petrov Corrie M. Whisner |
| author_sort | Magdalena Olson |
| collection | DOAJ |
| description | This study examines how feeding, sleep, and growth during infancy impact the gut microbiome (GM) in toddlers. The research was conducted on toddlers (<i>n</i> = 36), born to Latina women of low-income with obesity. Their mothers completed retrospective feeding and sleeping questionnaires at 1, 6, and 12 months; at 36 months, fecal samples were collected. Sequencing of the 16S rRNA gene (V4 region) revealed that breastfeeding for at least 1 month and the introduction of solids before 6 months differentiated the GM in toddlerhood (Bray–Curtis, pseudo-F = 1.805, <i>p</i> = 0.018, and pseudo-F = 1.651, <i>p</i> = 0.044, respectively). Sleep had an effect across time; at 1 and 6 months of age, a lower proportion of nighttime sleep (relative to 24 h total sleep) was associated with a richer GM at three years of age (Shannon H = 4.395, <i>p</i> = 0.036 and OTU H = 5.559, <i>p</i> = 0.018, respectively). Toddlers experiencing rapid weight gain from birth to 6 months had lower phylogenetic diversity (Faith PD H = 3.633, <i>p</i> = 0.057). These findings suggest that early life nutrition, sleeping patterns, and growth rate in infancy may influence the GM composition. Further verification of these results with objective sleep data and a larger sample is needed. |
| first_indexed | 2024-04-24T17:59:40Z |
| format | Article |
| id | doaj.art-aed176ee1a87401cb96eada91a3d51b8 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-04-24T17:59:40Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-aed176ee1a87401cb96eada91a3d51b82024-03-27T13:55:47ZengMDPI AGMicroorganisms2076-26072024-03-0112354910.3390/microorganisms12030549Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut MicrobiomeMagdalena Olson0Samantha Toffoli1Kiley B. Vander Wyst2Fang Zhou3Elizabeth Reifsnider4Megan E. Petrov5Corrie M. Whisner6College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USACollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USACollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USACollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USAEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004, USAEdson College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ 85004, USACollege of Health Solutions, Arizona State University, Phoenix, AZ 85004, USAThis study examines how feeding, sleep, and growth during infancy impact the gut microbiome (GM) in toddlers. The research was conducted on toddlers (<i>n</i> = 36), born to Latina women of low-income with obesity. Their mothers completed retrospective feeding and sleeping questionnaires at 1, 6, and 12 months; at 36 months, fecal samples were collected. Sequencing of the 16S rRNA gene (V4 region) revealed that breastfeeding for at least 1 month and the introduction of solids before 6 months differentiated the GM in toddlerhood (Bray–Curtis, pseudo-F = 1.805, <i>p</i> = 0.018, and pseudo-F = 1.651, <i>p</i> = 0.044, respectively). Sleep had an effect across time; at 1 and 6 months of age, a lower proportion of nighttime sleep (relative to 24 h total sleep) was associated with a richer GM at three years of age (Shannon H = 4.395, <i>p</i> = 0.036 and OTU H = 5.559, <i>p</i> = 0.018, respectively). Toddlers experiencing rapid weight gain from birth to 6 months had lower phylogenetic diversity (Faith PD H = 3.633, <i>p</i> = 0.057). These findings suggest that early life nutrition, sleeping patterns, and growth rate in infancy may influence the GM composition. Further verification of these results with objective sleep data and a larger sample is needed.https://www.mdpi.com/2076-2607/12/3/5493-year-old gut microbiomeinfant sleepearly life behaviors |
| spellingShingle | Magdalena Olson Samantha Toffoli Kiley B. Vander Wyst Fang Zhou Elizabeth Reifsnider Megan E. Petrov Corrie M. Whisner Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome Microorganisms 3-year-old gut microbiome infant sleep early life behaviors |
| title | Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome |
| title_full | Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome |
| title_fullStr | Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome |
| title_full_unstemmed | Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome |
| title_short | Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome |
| title_sort | associations of infant feeding sleep and weight gain with the toddler gut microbiome |
| topic | 3-year-old gut microbiome infant sleep early life behaviors |
| url | https://www.mdpi.com/2076-2607/12/3/549 |
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