Micro-engineered architected metamaterials for cell and tissue engineering
Architected metamaterials are built upon the assembly of repeating cellular structures, exhibiting unprecedented mechanical properties attributed to the tunability of cellular geometries. They have demonstrated a wide range of applications in the optical and electromagnetic fields, and recently they...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Materials Today Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590049822000029 |
| _version_ | 1819003331043917824 |
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| author | Chenyan Wang Zacharias Vangelatos Costas P. Grigoropoulos Zhen Ma |
| author_facet | Chenyan Wang Zacharias Vangelatos Costas P. Grigoropoulos Zhen Ma |
| author_sort | Chenyan Wang |
| collection | DOAJ |
| description | Architected metamaterials are built upon the assembly of repeating cellular structures, exhibiting unprecedented mechanical properties attributed to the tunability of cellular geometries. They have demonstrated a wide range of applications in the optical and electromagnetic fields, and recently they are employed as advanced tissue engineering scaffolds. The microgeometry-driven strategy enlarges the design domain of scaffold features and enables more accurate manipulation of cell-material interactions. In this review, we introduce the most popular metamaterial designs in biomedical engineering and summarize their representative applications to fabricate in vitro models and in vivo implants. These studies validate the unique advantages of metamaterials in supporting mechanobiological studies and improving the functionality of tissue replacements. Nevertheless, the evolution of meta-biomaterials requires more detailed investigations of the relationship between structural designs and cell phenotypes as well as accurate theoretical models. |
| first_indexed | 2024-12-20T23:19:18Z |
| format | Article |
| id | doaj.art-aed55da40b884f43b3fc9f70f8e21aac |
| institution | Directory Open Access Journal |
| issn | 2590-0498 |
| language | English |
| last_indexed | 2024-12-20T23:19:18Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Advances |
| spelling | doaj.art-aed55da40b884f43b3fc9f70f8e21aac2022-12-21T19:23:34ZengElsevierMaterials Today Advances2590-04982022-03-0113100206Micro-engineered architected metamaterials for cell and tissue engineeringChenyan Wang0Zacharias Vangelatos1Costas P. Grigoropoulos2Zhen Ma3Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse, NY, 13244, USA; BioInspired Syracuse Institute for Material and Living Systems, Syracuse University, Syracuse, NY, 13244, USADepartment of Mechanical Engineering, University of California, Berkeley, CA, 94720, USADepartment of Mechanical Engineering, University of California, Berkeley, CA, 94720, USADepartment of Biomedical & Chemical Engineering, Syracuse University, Syracuse, NY, 13244, USA; BioInspired Syracuse Institute for Material and Living Systems, Syracuse University, Syracuse, NY, 13244, USA; Corresponding author. Department of Biomedical & Chemical Engineering, Syracuse University, Syracuse, NY, 13244, USA.Architected metamaterials are built upon the assembly of repeating cellular structures, exhibiting unprecedented mechanical properties attributed to the tunability of cellular geometries. They have demonstrated a wide range of applications in the optical and electromagnetic fields, and recently they are employed as advanced tissue engineering scaffolds. The microgeometry-driven strategy enlarges the design domain of scaffold features and enables more accurate manipulation of cell-material interactions. In this review, we introduce the most popular metamaterial designs in biomedical engineering and summarize their representative applications to fabricate in vitro models and in vivo implants. These studies validate the unique advantages of metamaterials in supporting mechanobiological studies and improving the functionality of tissue replacements. Nevertheless, the evolution of meta-biomaterials requires more detailed investigations of the relationship between structural designs and cell phenotypes as well as accurate theoretical models.http://www.sciencedirect.com/science/article/pii/S2590049822000029Mechanical metamaterialsBiomaterialsTissue engineeringMeta-implants |
| spellingShingle | Chenyan Wang Zacharias Vangelatos Costas P. Grigoropoulos Zhen Ma Micro-engineered architected metamaterials for cell and tissue engineering Materials Today Advances Mechanical metamaterials Biomaterials Tissue engineering Meta-implants |
| title | Micro-engineered architected metamaterials for cell and tissue engineering |
| title_full | Micro-engineered architected metamaterials for cell and tissue engineering |
| title_fullStr | Micro-engineered architected metamaterials for cell and tissue engineering |
| title_full_unstemmed | Micro-engineered architected metamaterials for cell and tissue engineering |
| title_short | Micro-engineered architected metamaterials for cell and tissue engineering |
| title_sort | micro engineered architected metamaterials for cell and tissue engineering |
| topic | Mechanical metamaterials Biomaterials Tissue engineering Meta-implants |
| url | http://www.sciencedirect.com/science/article/pii/S2590049822000029 |
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