Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study
Abstract Objective Mesencephalic astrocyte-derived neurotrophic factor (MANF) expressions are dramatically up-regulated in injured brain tissues, thereby conferring neurological protective effects. We intended to determine significance of serum MANF as a prognostic biomarker of intracerebral hemorrh...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-023-03254-y |
| _version_ | 1827933350685310976 |
|---|---|
| author | Cheng-Liang Zhang Ling-Li Fang Chuan-Liu Wang Ping Li Ming Yang Jian-Wei Xu |
| author_facet | Cheng-Liang Zhang Ling-Li Fang Chuan-Liu Wang Ping Li Ming Yang Jian-Wei Xu |
| author_sort | Cheng-Liang Zhang |
| collection | DOAJ |
| description | Abstract Objective Mesencephalic astrocyte-derived neurotrophic factor (MANF) expressions are dramatically up-regulated in injured brain tissues, thereby conferring neurological protective effects. We intended to determine significance of serum MANF as a prognostic biomarker of intracerebral hemorrhage (ICH). Methods In this prospective, observational study done from February 2018 to July 2021, 124 patients with new-onset primary supratentorial ICH were consecutively enrolled. Also, a group of 124 healthy individuals constituted controls. Their serum MANF levels were detected using the Enzyme-Linked Immunosorbent Assay. National Institutes of Health Stroke Scale (NIHSS) and hematoma volume were designated as the two severity indicators. Early neurologic deterioration (END) was referred to as an increase of 4 or greater points in NIHSS scores or death at post-stroke 24 h. Post-stroke 90-day modified Rankin scale (mRS) scores of 3–6 was considered as a poor prognosis. Serum MANF levels were analyzed using multivariate analysis with respect to its association with stroke severity and prognosis. Results Patients, in comparison to controls, displayed markedly elevated serum MANF levels (median, 24.7 versus 2.7 ng/ml; P < 0.001), and serum MANF levels were independently correlated with NIHSS scores (beta, 3.912; 95% confidence interval (CI), 1.623-6.200; VIF = 2.394; t = 3.385; P = 0.002), hematoma volumes (beta, 1.688; 95% CI, 0.764–2.612; VIF = 2.661; t = 3.617; P = 0.001) and mRS scores (beta, 0.018; 95% CI, 0.013–0.023; VIF = 1.984; t = 2.047; P = 0.043). Serum MANF levels significantly predicted END and poor 90-day prognosis with areas under receiver operating characteristic curve at 0.752 and 0.787 respectively. END and prognostic predictive abilities were similar between serum MANF levels and NIHSS scores plus hematoma volumes (all P > 0.05). Combination of serum MANF levels with NIHSS scores and hematoma volumes had significantly higher prognostic capability than each of them (both P < 0.05). Serum MANF levels above 52.5 ng/ml and 62.0 ng/ml distinguished development of END and poor prognosis respectively with median-high sensitivity and specificity values. Using multivariate analysis, serum MANF levels > 52.5 ng/ml predicted END with odds ratio (OR) value of 2.713 (95% CI, 1.004–7.330; P = 0.042) and > 62.0 ng/ml predicted a poor prognosis with OR value of 3.848 (95% CI, 1.193–12.417; P = 0.024). Using restricted cubic spline, there was a linear correlation between serum MANF levels and poor prognosis or END risk (both P > 0.05). Nomograms were well established to predict END and a poor 90-day prognosis. Under calibration curve, such combination models were comparatively stable (using Hosmer & Lemeshow test, both P > 0.05). Conclusion Increased serum MANF levels after ICH, in independent correlation with disease severity, independently distinguished risks of END and 90-day poor prognosis. Therefore, serum MANF may be a potential prognostic biomarker of ICH. |
| first_indexed | 2024-03-13T07:23:32Z |
| format | Article |
| id | doaj.art-aed593fd4af74701b247229ff1696a05 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-13T07:23:32Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-aed593fd4af74701b247229ff1696a052023-06-04T11:31:57ZengBMCBMC Neurology1471-23772023-06-0123111510.1186/s12883-023-03254-yPrognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational studyCheng-Liang Zhang0Ling-Li Fang1Chuan-Liu Wang2Ping Li3Ming Yang4Jian-Wei Xu5Department of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Clinical Pharmacy, The Second People’s Hospital of Yuhang DistrictDepartment of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Respiratory and Critical Care Medicine, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s HospitalDepartment of Clinic, The Quzhou Hospital of TCM, Quzhou TCM Hospital at the Junction of Four Provinces Affiliated to Zhejiang Chinese Medical UniversityAbstract Objective Mesencephalic astrocyte-derived neurotrophic factor (MANF) expressions are dramatically up-regulated in injured brain tissues, thereby conferring neurological protective effects. We intended to determine significance of serum MANF as a prognostic biomarker of intracerebral hemorrhage (ICH). Methods In this prospective, observational study done from February 2018 to July 2021, 124 patients with new-onset primary supratentorial ICH were consecutively enrolled. Also, a group of 124 healthy individuals constituted controls. Their serum MANF levels were detected using the Enzyme-Linked Immunosorbent Assay. National Institutes of Health Stroke Scale (NIHSS) and hematoma volume were designated as the two severity indicators. Early neurologic deterioration (END) was referred to as an increase of 4 or greater points in NIHSS scores or death at post-stroke 24 h. Post-stroke 90-day modified Rankin scale (mRS) scores of 3–6 was considered as a poor prognosis. Serum MANF levels were analyzed using multivariate analysis with respect to its association with stroke severity and prognosis. Results Patients, in comparison to controls, displayed markedly elevated serum MANF levels (median, 24.7 versus 2.7 ng/ml; P < 0.001), and serum MANF levels were independently correlated with NIHSS scores (beta, 3.912; 95% confidence interval (CI), 1.623-6.200; VIF = 2.394; t = 3.385; P = 0.002), hematoma volumes (beta, 1.688; 95% CI, 0.764–2.612; VIF = 2.661; t = 3.617; P = 0.001) and mRS scores (beta, 0.018; 95% CI, 0.013–0.023; VIF = 1.984; t = 2.047; P = 0.043). Serum MANF levels significantly predicted END and poor 90-day prognosis with areas under receiver operating characteristic curve at 0.752 and 0.787 respectively. END and prognostic predictive abilities were similar between serum MANF levels and NIHSS scores plus hematoma volumes (all P > 0.05). Combination of serum MANF levels with NIHSS scores and hematoma volumes had significantly higher prognostic capability than each of them (both P < 0.05). Serum MANF levels above 52.5 ng/ml and 62.0 ng/ml distinguished development of END and poor prognosis respectively with median-high sensitivity and specificity values. Using multivariate analysis, serum MANF levels > 52.5 ng/ml predicted END with odds ratio (OR) value of 2.713 (95% CI, 1.004–7.330; P = 0.042) and > 62.0 ng/ml predicted a poor prognosis with OR value of 3.848 (95% CI, 1.193–12.417; P = 0.024). Using restricted cubic spline, there was a linear correlation between serum MANF levels and poor prognosis or END risk (both P > 0.05). Nomograms were well established to predict END and a poor 90-day prognosis. Under calibration curve, such combination models were comparatively stable (using Hosmer & Lemeshow test, both P > 0.05). Conclusion Increased serum MANF levels after ICH, in independent correlation with disease severity, independently distinguished risks of END and 90-day poor prognosis. Therefore, serum MANF may be a potential prognostic biomarker of ICH.https://doi.org/10.1186/s12883-023-03254-yMesencephalic astrocyte-derived neurotrophic factorIntracerebral hemorrhageEarly neurologic deteriorationPrognosisSeverity |
| spellingShingle | Cheng-Liang Zhang Ling-Li Fang Chuan-Liu Wang Ping Li Ming Yang Jian-Wei Xu Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study BMC Neurology Mesencephalic astrocyte-derived neurotrophic factor Intracerebral hemorrhage Early neurologic deterioration Prognosis Severity |
| title | Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study |
| title_full | Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study |
| title_fullStr | Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study |
| title_full_unstemmed | Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study |
| title_short | Prognostic potential of serum mesencephalic astrocyte-derived neurotrophic factor in acute intracerebral hemorrhage: a prospective observational study |
| title_sort | prognostic potential of serum mesencephalic astrocyte derived neurotrophic factor in acute intracerebral hemorrhage a prospective observational study |
| topic | Mesencephalic astrocyte-derived neurotrophic factor Intracerebral hemorrhage Early neurologic deterioration Prognosis Severity |
| url | https://doi.org/10.1186/s12883-023-03254-y |
| work_keys_str_mv | AT chengliangzhang prognosticpotentialofserummesencephalicastrocytederivedneurotrophicfactorinacuteintracerebralhemorrhageaprospectiveobservationalstudy AT linglifang prognosticpotentialofserummesencephalicastrocytederivedneurotrophicfactorinacuteintracerebralhemorrhageaprospectiveobservationalstudy AT chuanliuwang prognosticpotentialofserummesencephalicastrocytederivedneurotrophicfactorinacuteintracerebralhemorrhageaprospectiveobservationalstudy AT pingli prognosticpotentialofserummesencephalicastrocytederivedneurotrophicfactorinacuteintracerebralhemorrhageaprospectiveobservationalstudy AT mingyang prognosticpotentialofserummesencephalicastrocytederivedneurotrophicfactorinacuteintracerebralhemorrhageaprospectiveobservationalstudy AT jianweixu prognosticpotentialofserummesencephalicastrocytederivedneurotrophicfactorinacuteintracerebralhemorrhageaprospectiveobservationalstudy |