Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate N...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07277-9 |
| _version_ | 1831771429233754112 |
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| author | Fangjie Wang Meng Meng Banghui Mo Yao Yang Yan Ji Pei Huang Wenjing Lai Xiaodong Pan Tingting You Hongqin Luo Xiao Guan Yafei Deng Shunzong Yuan Jianhong Chu Michael Namaka Tiffany Hughes Lilin Ye Jianhua Yu Xiaohui Li Youcai Deng |
| author_facet | Fangjie Wang Meng Meng Banghui Mo Yao Yang Yan Ji Pei Huang Wenjing Lai Xiaodong Pan Tingting You Hongqin Luo Xiao Guan Yafei Deng Shunzong Yuan Jianhong Chu Michael Namaka Tiffany Hughes Lilin Ye Jianhua Yu Xiaohui Li Youcai Deng |
| author_sort | Fangjie Wang |
| collection | DOAJ |
| description | The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate NK maturation and effector functions. |
| first_indexed | 2024-12-22T07:59:07Z |
| format | Article |
| id | doaj.art-aed5a9a2b75b4c99ac71c6c1c1c72f87 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:59:07Z |
| publishDate | 2018-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-aed5a9a2b75b4c99ac71c6c1c1c72f872022-12-21T18:33:18ZengNature PortfolioNature Communications2041-17232018-11-019111710.1038/s41467-018-07277-9Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector functionFangjie Wang0Meng Meng1Banghui Mo2Yao Yang3Yan Ji4Pei Huang5Wenjing Lai6Xiaodong Pan7Tingting You8Hongqin Luo9Xiao Guan10Yafei Deng11Shunzong Yuan12Jianhong Chu13Michael Namaka14Tiffany Hughes15Lilin Ye16Jianhua Yu17Xiaohui Li18Youcai Deng19Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Department of Laboratory Medicine, PLA 307 HospitalInstitute of Blood and Marrow Transplantation, Soochow UniversityInstitute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)The Ohio State University Comprehensive Cancer Center and the James Cancer HospitalInstitute of Immunology, Army Medical University (Third Military Medical University)The Ohio State University Comprehensive Cancer Center and the James Cancer HospitalInstitute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)Institute of Materia Medica, College of Pharmacy, Army Medical University (Third Military Medical University)The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to variegate cytokine and cellular signaling and modulate NK maturation and effector functions.https://doi.org/10.1038/s41467-018-07277-9 |
| spellingShingle | Fangjie Wang Meng Meng Banghui Mo Yao Yang Yan Ji Pei Huang Wenjing Lai Xiaodong Pan Tingting You Hongqin Luo Xiao Guan Yafei Deng Shunzong Yuan Jianhong Chu Michael Namaka Tiffany Hughes Lilin Ye Jianhua Yu Xiaohui Li Youcai Deng Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function Nature Communications |
| title | Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function |
| title_full | Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function |
| title_fullStr | Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function |
| title_full_unstemmed | Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function |
| title_short | Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function |
| title_sort | crosstalks between mtorc1 and mtorc2 variagate cytokine signaling to control nk maturation and effector function |
| url | https://doi.org/10.1038/s41467-018-07277-9 |
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