Women with polycystic ovary syndrome and risk of cardiovascular disease
Background: Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk. Methods: Fifty-four young women wit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2017-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581703259P.pdf |
| _version_ | 1819225889836105728 |
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| author | Perović-Blagojević Iva Eror Tatjana Pelivanović Jovana Jelić Svetlana Kotur-Stevuljević Jelena Ignjatović Svetlana |
| author_facet | Perović-Blagojević Iva Eror Tatjana Pelivanović Jovana Jelić Svetlana Kotur-Stevuljević Jelena Ignjatović Svetlana |
| author_sort | Perović-Blagojević Iva |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk. Methods: Fifty-four young women with PCOS (22 obese and 32 normal weight) were compared to 46 respective controls (17 obese and 29 normal weight). Anthropometric parameters, lipid status parameters, inflammation markers, concentrations of glucose, transaminases, sex and anterior pituitary hormones, sex hormone binding globulin (SHBG) and androgens were measured. Cardiovascular Risk Score (CVRS), indices for identifying Non-Alcoholic Fatty Liver Disease (NAFLD) and the Index of Central Obesity (ICO) were calculated. Results: Significantly higher CVRS values (p< 0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinogen (p< 0.001, p< 0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLd indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC>0.8) in identifying patients with increased cardiovascular risk (CVR). Conclusions: Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO. |
| first_indexed | 2024-12-23T10:16:46Z |
| format | Article |
| id | doaj.art-aed6f3a5140f419987c6412ce7390ad5 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-23T10:16:46Z |
| publishDate | 2017-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-aed6f3a5140f419987c6412ce7390ad52022-12-21T17:50:47ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662017-01-013632592691452-82581703259PWomen with polycystic ovary syndrome and risk of cardiovascular diseasePerović-Blagojević Iva0Eror Tatjana1Pelivanović Jovana2Jelić Svetlana3Kotur-Stevuljević Jelena4https://orcid.org/0000-0002-6980-3069Ignjatović Svetlana5https://orcid.org/0000-0001-9241-5737Clinical Hospital Center "Dr Dragisa Misovic - Dedinje", Department of Laboratory Diagnostic, BelgradeClinical Hospital Center "Dr Dragisa Misovic - Dedinje", Clinic of Internal Medicine, BelgradeUniversity of Belgrade, Faculty of Pharmacy, Department for Medical BiochemistryUniversity Hospital Medical Center "Bezanijska kosa", BelgradeUniversity of Belgrade, Faculty of Pharmacy, Department for Medical BiochemistryUniversity of Belgrade, Faculty of Pharmacy, Department for Medical Biochemistry + Clinical Center Serbia, Center for Medical Biochemistry, BelgradeBackground: Polycystic ovary syndrome (PCOS) is associated with reproductive and metabolic abnormalities. The aim of this study was to analyse risk of cardiovascular disease (CVD) in PCOS, to define individual risk factors and assess their ability to predict risk. Methods: Fifty-four young women with PCOS (22 obese and 32 normal weight) were compared to 46 respective controls (17 obese and 29 normal weight). Anthropometric parameters, lipid status parameters, inflammation markers, concentrations of glucose, transaminases, sex and anterior pituitary hormones, sex hormone binding globulin (SHBG) and androgens were measured. Cardiovascular Risk Score (CVRS), indices for identifying Non-Alcoholic Fatty Liver Disease (NAFLD) and the Index of Central Obesity (ICO) were calculated. Results: Significantly higher CVRS values (p< 0.05) were found in obese PCOS women compared to normal weight control and normal weight PCOS groups. Anthropometric parameters, lipid status parameters and fibrinogen (p< 0.001, p< 0.01) were higher in women with higher CVRS. The most significant CVRS predictors in all PCOS women were SHBG, androstenedione, follicle-stimulating hormone (FSH) and dehydroepiandrosterone sulphate (DHEAS). ICO and all NAFLd indices exhibited significant positive correlation with CVRS and a model consisting of these indices provided good diagnostic accuracy (AUC>0.8) in identifying patients with increased cardiovascular risk (CVR). Conclusions: Obesity is a higher risk for developing CVD than PCOS alone. Anthropometric parameters, lipid parameters, fibrinogen, NAFLD indices and ICO increase CVR in PCOS women. For the prediction of CVR in PCOS, we suggest a combination of NAFLD indices and ICO.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581703259P.pdfpolycystic ovary syndromecardiovascular diseasecardiovascular risk scorenon-alcoholic fatty liver diseasecentral obesity index |
| spellingShingle | Perović-Blagojević Iva Eror Tatjana Pelivanović Jovana Jelić Svetlana Kotur-Stevuljević Jelena Ignjatović Svetlana Women with polycystic ovary syndrome and risk of cardiovascular disease Journal of Medical Biochemistry polycystic ovary syndrome cardiovascular disease cardiovascular risk score non-alcoholic fatty liver disease central obesity index |
| title | Women with polycystic ovary syndrome and risk of cardiovascular disease |
| title_full | Women with polycystic ovary syndrome and risk of cardiovascular disease |
| title_fullStr | Women with polycystic ovary syndrome and risk of cardiovascular disease |
| title_full_unstemmed | Women with polycystic ovary syndrome and risk of cardiovascular disease |
| title_short | Women with polycystic ovary syndrome and risk of cardiovascular disease |
| title_sort | women with polycystic ovary syndrome and risk of cardiovascular disease |
| topic | polycystic ovary syndrome cardiovascular disease cardiovascular risk score non-alcoholic fatty liver disease central obesity index |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2017/1452-82581703259P.pdf |
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