A bacteriophage endolysin that eliminates intracellular streptococci

A bacteriophage endolysin that eliminates intracellular streptococci

PlyC, a bacteriophage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact. Here, we demonstrate that PlyC is a potent agent for controlling intracellular Spy that often underlies refractory infections. We show that the PlyC holoenzyme, mediated by its PlyCB subunit, crosses epithelial c...

Full description

Bibliographic Details
Main Authors: Yang Shen, Marilia Barros, Tarek Vennemann, D Travis Gallagher, Yizhou Yin, Sara B Linden, Ryan D Heselpoth, Dennis J Spencer, David M Donovan, John Moult, Vincent A Fischetti, Frank Heinrich, Mathias Lösche, Daniel C Nelson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
bacteriophage
membrane protein
endolysin
structure/function
Online Access:https://elifesciences.org/articles/13152

Similar Items

Similar Items