Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials
Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-02-01
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| Series: | Nanomaterials |
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| Online Access: | http://www.mdpi.com/2079-4991/7/2/43 |
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| author | Ioana Turcu Irina Zarafu Marcela Popa Mariana Carmen Chifiriuc Coralia Bleotu Daniela Culita Corneliu Ghica Petre Ionita |
| author_facet | Ioana Turcu Irina Zarafu Marcela Popa Mariana Carmen Chifiriuc Coralia Bleotu Daniela Culita Corneliu Ghica Petre Ionita |
| author_sort | Ioana Turcu |
| collection | DOAJ |
| description | Water soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activity, as well as for their influence on mammalian cell viability and cellular cycle. In all cases a decreased antimicrobial activity of the obtained bioactive nanoparticles was observed as compared with the organic compounds, proving that a possible inactivation of the bioactive groups could occur during functionalization. However, both the gold nanoparticles as well as the functionalized bioactive nanosystems proved to be biocompatible at concentrations lower than 50 µg/mL, as revealed by the cellular viability and cell cycle assay, demonstrating their potential for the development of novel antimicrobial agents. |
| first_indexed | 2024-12-21T02:07:41Z |
| format | Article |
| id | doaj.art-aed87370d61c4118b3ac61c88b9782c9 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-21T02:07:41Z |
| publishDate | 2017-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-aed87370d61c4118b3ac61c88b9782c92022-12-21T19:19:27ZengMDPI AGNanomaterials2079-49912017-02-01724310.3390/nano7020043nano7020043Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive MaterialsIoana Turcu0Irina Zarafu1Marcela Popa2Mariana Carmen Chifiriuc3Coralia Bleotu4Daniela Culita5Corneliu Ghica6Petre Ionita7Department of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, 90-92 Panduri, 050663 Bucharest, RomaniaDepartment of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, 90-92 Panduri, 050663 Bucharest, RomaniaMicrobiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Way, 060101 Bucharest, RomaniaMicrobiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Way, 060101 Bucharest, RomaniaMicrobiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Way, 060101 Bucharest, RomaniaInstitute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, RomaniaNational Institute of Materials Physics, Laboratory of Atomic Structures and Defects in Advanced Materials, Atomistilor 105 bis, 077125 Magurele, RomaniaDepartment of Organic Chemistry, Biochemistry and Catalysis, University of Bucharest, 90-92 Panduri, 050663 Bucharest, RomaniaWater soluble gold nanoparticles protected by lipoic acid were obtained and further functionalized by standard coupling reaction with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5 ether. Derivatives of lipoic acid with 1-naphtylamine, 4-aminoantipyrine, and 4′-aminobenzo-15-crown-5 ether were also obtained and characterized. All these were tested for their antimicrobial activity, as well as for their influence on mammalian cell viability and cellular cycle. In all cases a decreased antimicrobial activity of the obtained bioactive nanoparticles was observed as compared with the organic compounds, proving that a possible inactivation of the bioactive groups could occur during functionalization. However, both the gold nanoparticles as well as the functionalized bioactive nanosystems proved to be biocompatible at concentrations lower than 50 µg/mL, as revealed by the cellular viability and cell cycle assay, demonstrating their potential for the development of novel antimicrobial agents.http://www.mdpi.com/2079-4991/7/2/43gold nanoparticleslipoic acidthioctic acidantimicrobialcytotoxicitycellular cycle |
| spellingShingle | Ioana Turcu Irina Zarafu Marcela Popa Mariana Carmen Chifiriuc Coralia Bleotu Daniela Culita Corneliu Ghica Petre Ionita Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials Nanomaterials gold nanoparticles lipoic acid thioctic acid antimicrobial cytotoxicity cellular cycle |
| title | Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials |
| title_full | Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials |
| title_fullStr | Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials |
| title_full_unstemmed | Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials |
| title_short | Lipoic Acid Gold Nanoparticles Functionalized with Organic Compounds as Bioactive Materials |
| title_sort | lipoic acid gold nanoparticles functionalized with organic compounds as bioactive materials |
| topic | gold nanoparticles lipoic acid thioctic acid antimicrobial cytotoxicity cellular cycle |
| url | http://www.mdpi.com/2079-4991/7/2/43 |
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