Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner
The metabolic syndrome (MS) has become one of the main problems in public health. Tea polyphenols (TPs), the main bioactive components of tea, has been claimed to have the potential to regulate metabolism and effectively prevent or mitigate the MS. However, many studies into the effects of TPs on MS...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2022-01-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000689 |
| _version_ | 1797714443685068800 |
|---|---|
| author | Hui Ma Yaozhong Hu Bowei Zhang Zeping Shao Eugeni Roura Shuo Wang |
| author_facet | Hui Ma Yaozhong Hu Bowei Zhang Zeping Shao Eugeni Roura Shuo Wang |
| author_sort | Hui Ma |
| collection | DOAJ |
| description | The metabolic syndrome (MS) has become one of the main problems in public health. Tea polyphenols (TPs), the main bioactive components of tea, has been claimed to have the potential to regulate metabolism and effectively prevent or mitigate the MS. However, many studies into the effects of TPs on MS have provided conflicting findings and the underlying mechanism has been elusive. The predominant TPs in unfermentedand and fermented tea are catechins and oxidized polyphenols (theaflavins and thearubigins), both of which have low bioavailability and reach the colon where most gut microbes inhabit. Gut microbiota has been demonstrated to be tightly associated with host metabolism. The interactions between TPs and gut microbiota will lead to the alterations of gut microbiota composition and the production of metabolites including short chain fatty acids, bile acids, amino acids and TPs derived metabolites, accordingly exerting their biological effects both locally and systemically. This review highlighted the contribution of metabolites and specific gut bacteria in the process of TPs intervention on the MS and further discuss how TPs impact the MS via gut microbiota from the viewpoint of gut organ/tissue axis. |
| first_indexed | 2024-03-12T07:52:04Z |
| format | Article |
| id | doaj.art-aed8c76868b8402c92561241d7e7b46f |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T07:52:04Z |
| publishDate | 2022-01-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-aed8c76868b8402c92561241d7e7b46f2023-09-02T20:33:23ZengTsinghua University PressFood Science and Human Wellness2213-45302022-01-011111121Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target mannerHui Ma0Yaozhong Hu1Bowei Zhang2Zeping Shao3Eugeni Roura4Shuo Wang5Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, ChinaTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, ChinaTianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, ChinaCentre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, QLD 4072, AustraliaCentre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, QLD 4072, Australia; Corresponding authors.Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China; Corresponding authors.The metabolic syndrome (MS) has become one of the main problems in public health. Tea polyphenols (TPs), the main bioactive components of tea, has been claimed to have the potential to regulate metabolism and effectively prevent or mitigate the MS. However, many studies into the effects of TPs on MS have provided conflicting findings and the underlying mechanism has been elusive. The predominant TPs in unfermentedand and fermented tea are catechins and oxidized polyphenols (theaflavins and thearubigins), both of which have low bioavailability and reach the colon where most gut microbes inhabit. Gut microbiota has been demonstrated to be tightly associated with host metabolism. The interactions between TPs and gut microbiota will lead to the alterations of gut microbiota composition and the production of metabolites including short chain fatty acids, bile acids, amino acids and TPs derived metabolites, accordingly exerting their biological effects both locally and systemically. This review highlighted the contribution of metabolites and specific gut bacteria in the process of TPs intervention on the MS and further discuss how TPs impact the MS via gut microbiota from the viewpoint of gut organ/tissue axis.http://www.sciencedirect.com/science/article/pii/S2213453021000689Tea polyphenolsGut microbiotaMetabolic syndromeMetabolitesGut organ/tissue axis |
| spellingShingle | Hui Ma Yaozhong Hu Bowei Zhang Zeping Shao Eugeni Roura Shuo Wang Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner Food Science and Human Wellness Tea polyphenols Gut microbiota Metabolic syndrome Metabolites Gut organ/tissue axis |
| title | Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner |
| title_full | Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner |
| title_fullStr | Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner |
| title_full_unstemmed | Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner |
| title_short | Tea polyphenol – gut microbiota interactions: hints on improving the metabolic syndrome in a multi-element and multi-target manner |
| title_sort | tea polyphenol gut microbiota interactions hints on improving the metabolic syndrome in a multi element and multi target manner |
| topic | Tea polyphenols Gut microbiota Metabolic syndrome Metabolites Gut organ/tissue axis |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000689 |
| work_keys_str_mv | AT huima teapolyphenolgutmicrobiotainteractionshintsonimprovingthemetabolicsyndromeinamultielementandmultitargetmanner AT yaozhonghu teapolyphenolgutmicrobiotainteractionshintsonimprovingthemetabolicsyndromeinamultielementandmultitargetmanner AT boweizhang teapolyphenolgutmicrobiotainteractionshintsonimprovingthemetabolicsyndromeinamultielementandmultitargetmanner AT zepingshao teapolyphenolgutmicrobiotainteractionshintsonimprovingthemetabolicsyndromeinamultielementandmultitargetmanner AT eugeniroura teapolyphenolgutmicrobiotainteractionshintsonimprovingthemetabolicsyndromeinamultielementandmultitargetmanner AT shuowang teapolyphenolgutmicrobiotainteractionshintsonimprovingthemetabolicsyndromeinamultielementandmultitargetmanner |