Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion
Background. Hepatocellular carcinoma (HCC) is a leading cause of cancer morbidity and mortality. Findings of microvascular invasion (MVI) in patients with HCC have emerged as an important prognostic factor for poor survival after tumor resection. Aim. This study evaluated the relation between MVI an...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2023/5727701 |
| _version_ | 1797809182593777664 |
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| author | Arnold Nongmoh Forlemu Raissa Nana Sede Mbakop Praneeth Bandaru Vijay Gayam Hamsika Moparty Tomoki Sempokuya Faruq Pradhan Madhavi Reddy Marco Olivera |
| author_facet | Arnold Nongmoh Forlemu Raissa Nana Sede Mbakop Praneeth Bandaru Vijay Gayam Hamsika Moparty Tomoki Sempokuya Faruq Pradhan Madhavi Reddy Marco Olivera |
| author_sort | Arnold Nongmoh Forlemu |
| collection | DOAJ |
| description | Background. Hepatocellular carcinoma (HCC) is a leading cause of cancer morbidity and mortality. Findings of microvascular invasion (MVI) in patients with HCC have emerged as an important prognostic factor for poor survival after tumor resection. Aim. This study evaluated the relation between MVI and HCC within various anatomical Couinaud’s segments of the liver. Method. A multicenter retrospective review of HCC records was conducted from 2012 to 2017. HCC cases were identified using ICD-9 and 10 codes 155, C22.0, and C22.8. HCC patients who underwent liver transplants were included in this study. Liver segment of the location of HCC was obtained from radiographic records, and MVI information was obtained from pathology reports. Segmental distributions of HCC in MVI versus non-MVI groups were compared using Wilcoxon rank sum tests. p value was set at <0.05. Results. We analyzed 120 HCC patients who underwent liver transplantation. The mean age of our cohort was 57 years, and the most common etiology of liver disease was hepatitis C at 58.3%. The median HCC size was 3.1 cm, and MVI was present in 23.3% of the explanted specimens. MVI was 2 to 3 times significantly higher in patients with HCC affecting segments 2 and 3 and segments 4b and 5 (p=0.01). Moreover, median survival was significantly lower in patients with MVI versus those without MVI (50 vs. 137 months, p<0.05). Conclusion. MVI was significantly higher in HCC tumors located in liver segments 2 and 3 and 4b and 5, and survival was lower in patients with MVI compared with those without. |
| first_indexed | 2024-03-13T06:48:41Z |
| format | Article |
| id | doaj.art-aed8cb924645443587eb54c66c40e306 |
| institution | Directory Open Access Journal |
| issn | 2090-3456 |
| language | English |
| last_indexed | 2024-03-13T06:48:41Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj.art-aed8cb924645443587eb54c66c40e3062023-06-08T00:00:03ZengHindawi LimitedInternational Journal of Hepatology2090-34562023-01-01202310.1155/2023/5727701Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular InvasionArnold Nongmoh Forlemu0Raissa Nana Sede Mbakop1Praneeth Bandaru2Vijay Gayam3Hamsika Moparty4Tomoki Sempokuya5Faruq Pradhan6Madhavi Reddy7Marco Olivera8Department of Gastroenterology and HepatologyDepartment of Internal MedicineDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Internal MedicineDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyDepartment of Gastroenterology and HepatologyBackground. Hepatocellular carcinoma (HCC) is a leading cause of cancer morbidity and mortality. Findings of microvascular invasion (MVI) in patients with HCC have emerged as an important prognostic factor for poor survival after tumor resection. Aim. This study evaluated the relation between MVI and HCC within various anatomical Couinaud’s segments of the liver. Method. A multicenter retrospective review of HCC records was conducted from 2012 to 2017. HCC cases were identified using ICD-9 and 10 codes 155, C22.0, and C22.8. HCC patients who underwent liver transplants were included in this study. Liver segment of the location of HCC was obtained from radiographic records, and MVI information was obtained from pathology reports. Segmental distributions of HCC in MVI versus non-MVI groups were compared using Wilcoxon rank sum tests. p value was set at <0.05. Results. We analyzed 120 HCC patients who underwent liver transplantation. The mean age of our cohort was 57 years, and the most common etiology of liver disease was hepatitis C at 58.3%. The median HCC size was 3.1 cm, and MVI was present in 23.3% of the explanted specimens. MVI was 2 to 3 times significantly higher in patients with HCC affecting segments 2 and 3 and segments 4b and 5 (p=0.01). Moreover, median survival was significantly lower in patients with MVI versus those without MVI (50 vs. 137 months, p<0.05). Conclusion. MVI was significantly higher in HCC tumors located in liver segments 2 and 3 and 4b and 5, and survival was lower in patients with MVI compared with those without.http://dx.doi.org/10.1155/2023/5727701 |
| spellingShingle | Arnold Nongmoh Forlemu Raissa Nana Sede Mbakop Praneeth Bandaru Vijay Gayam Hamsika Moparty Tomoki Sempokuya Faruq Pradhan Madhavi Reddy Marco Olivera Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion International Journal of Hepatology |
| title | Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion |
| title_full | Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion |
| title_fullStr | Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion |
| title_full_unstemmed | Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion |
| title_short | Liver Segment Disposition of Hepatocellular Carcinoma Predicts Microvascular Invasion |
| title_sort | liver segment disposition of hepatocellular carcinoma predicts microvascular invasion |
| url | http://dx.doi.org/10.1155/2023/5727701 |
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