Evolutionary Trends in RNA Base Selectivity Within the RNase A Superfamily

Evolutionary Trends in RNA Base Selectivity Within the RNase A Superfamily

There is a growing interest in the pharmaceutical industry to design novel tailored drugs for RNA targeting. The vertebrate-specific RNase A superfamily is nowadays one of the best characterized family of enzymes and comprises proteins involved in host defense with specific cytotoxic and immune-modu...

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Bibliographic Details
Main Authors: Guillem Prats-Ejarque, Lu Lu, Vivian A. Salazar, Mohammed Moussaoui, Ester Boix
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
RNase
RNA
purine
catalysis
molecular dynamics
evolution
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01170/full

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