Clinical and Laboratory Diagnosis of Legionella Pneumonia
Legionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/2/280 |
| _version_ | 1797443790196178944 |
|---|---|
| author | Lu Bai Wei Yang Yuanyuan Li |
| author_facet | Lu Bai Wei Yang Yuanyuan Li |
| author_sort | Lu Bai |
| collection | DOAJ |
| description | Legionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do not meet the clinical need for rapid and accurate diagnosis, especially for critically ill patients. So far, pathogenic detection techniques including serological assays, urinary antigen tests, and mass spectrometry, as well as nucleic acid amplification technique, have been developed, and each has its own advantages and limitations. This review summarizes the clinical characteristics and imaging findings of Legionella pneumonia, then discusses the advances, advantages, and limitations of the various pathogenetic detection techniques used for Legionella pneumonia diagnosis. The aim is to provide rapid and accurate guiding options for early identification and diagnosis of Legionella pneumonia in clinical practice, further easing healthcare burden. |
| first_indexed | 2024-03-09T13:03:04Z |
| format | Article |
| id | doaj.art-aedd439d0edf4ad8b108ed2c4f62b732 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T13:03:04Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-aedd439d0edf4ad8b108ed2c4f62b7322023-11-30T21:52:31ZengMDPI AGDiagnostics2075-44182023-01-0113228010.3390/diagnostics13020280Clinical and Laboratory Diagnosis of Legionella PneumoniaLu Bai0Wei Yang1Yuanyuan Li2Department of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha 410008, ChinaLegionella pneumonia is a relatively rare but extremely progressive pulmonary infection with high mortality. Traditional cultural isolation remains the gold standard for the diagnosis of Legionella pneumonia. However, its harsh culture conditions, long turnaround time, and suboptimal sensitivity do not meet the clinical need for rapid and accurate diagnosis, especially for critically ill patients. So far, pathogenic detection techniques including serological assays, urinary antigen tests, and mass spectrometry, as well as nucleic acid amplification technique, have been developed, and each has its own advantages and limitations. This review summarizes the clinical characteristics and imaging findings of Legionella pneumonia, then discusses the advances, advantages, and limitations of the various pathogenetic detection techniques used for Legionella pneumonia diagnosis. The aim is to provide rapid and accurate guiding options for early identification and diagnosis of Legionella pneumonia in clinical practice, further easing healthcare burden.https://www.mdpi.com/2075-4418/13/2/280Legionella pneumoniapathogenetic diagnosisclinical characteristicsimaging findings |
| spellingShingle | Lu Bai Wei Yang Yuanyuan Li Clinical and Laboratory Diagnosis of Legionella Pneumonia Diagnostics Legionella pneumonia pathogenetic diagnosis clinical characteristics imaging findings |
| title | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
| title_full | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
| title_fullStr | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
| title_full_unstemmed | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
| title_short | Clinical and Laboratory Diagnosis of Legionella Pneumonia |
| title_sort | clinical and laboratory diagnosis of legionella pneumonia |
| topic | Legionella pneumonia pathogenetic diagnosis clinical characteristics imaging findings |
| url | https://www.mdpi.com/2075-4418/13/2/280 |
| work_keys_str_mv | AT lubai clinicalandlaboratorydiagnosisoflegionellapneumonia AT weiyang clinicalandlaboratorydiagnosisoflegionellapneumonia AT yuanyuanli clinicalandlaboratorydiagnosisoflegionellapneumonia |