Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

The PKR-like endoplasmic reticulum kinase (PERK) arm of the Integrated Stress Response (ISR) is implicated in neurodegenerative disease, although the regulators and consequences of PERK activation following neuronal injury are poorly understood. Here we show that PERK signaling is a component of the...

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Bibliographic Details
Main Authors: Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh, Bei Wang, Joshua S Kaminker, Kevin Huang, Jeffrey Eastham-Anderson, Michael Siu, Zora Modrusan, Madeline M Farley, Marc Tessier-Lavigne, Joseph W Lewcock, Trent A Watkins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
optic nerve
unfolded protein response
apoptosis
neurodegeneration
axonal injury
stress response
Online Access:https://elifesciences.org/articles/20725

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