The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus

The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus

Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric ion channel complex. However, a functional understanding of the putati...

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Bibliographic Details
Main Authors: Kotdaji Ha, Mai Nobuhara, Qinzhe Wang, Rebecca V Walker, Feng Qian, Christoph Schartner, Erhu Cao, Markus Delling
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
primary cilia
polycystin channels
ADPKD
kidney
Online Access:https://elifesciences.org/articles/60684

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