The risk of respiratory tract infections and antibiotic use in a general population and among people with asthma
Aim The aim of this study was to investigate occupational, environmental, early life and other risk factors associated with respiratory infections and antibiotics use in a general population and among asthmatic individuals. Method This study included 15 842 participants of the Respiratory Health in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2022-01-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/8/1/00429-2021.full |
| _version_ | 1819018195893223424 |
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| author | Marta A. Kisiel Xingwu Zhou Eythor Björnsson Mathias Holm Anna Dahlman-Höglund Juan Wang Cecilie Svanes Dan Norbäck Karl A. Franklin Andrei Malinovschi Ane Johannessen Vivi Schlünssen Christer Janson |
| author_facet | Marta A. Kisiel Xingwu Zhou Eythor Björnsson Mathias Holm Anna Dahlman-Höglund Juan Wang Cecilie Svanes Dan Norbäck Karl A. Franklin Andrei Malinovschi Ane Johannessen Vivi Schlünssen Christer Janson |
| author_sort | Marta A. Kisiel |
| collection | DOAJ |
| description | Aim
The aim of this study was to investigate occupational, environmental, early life and other risk factors associated with respiratory infections and antibiotics use in a general population and among asthmatic individuals.
Method
This study included 15 842 participants of the Respiratory Health in Northern Europe (RHINE) study aged 25–54 years from five Nordic countries, who answered a questionnaire covering respiratory outcomes, exposures, demographic characteristics and numbers of infections and courses of antibiotics in the last 12 months. Multiple logistic regression with and without adjustment for age, sex, smoking status, body mass index and centre were used to study the risk of infection and antibiotics in relation to asthma, and also the association between infection and antibiotics and occupations.
Results
In the whole population, 11.6% reported having three or more respiratory infections, and 14.7% had used antibiotics because of respiratory tract infections within the last year. Asthmatic participants reported tripled odds for such infections (adjusted OR 2.98, 95% CI 2.53–3.52) and antibiotics use (adjusted OR 3.67, 95% CI 3.18–4.24) as compared to non-asthmatic participants. Both in the general and the asthmatic population, female sex, obesity and exposure to building dampness were associated with respiratory infections. Female sex and current smoking and living in Tartu were associated with antibiotic use. The use of antibiotics was doubled in people hospitalised for severe respiratory infection in childhood.
Conclusion
In this study we identified several factors associated with increased respiratory infections and use of antibiotics in a general population and among asthmatic individuals. The frequency of respiratory infections and subsequent antibiotic treatment were increased among those with asthma. |
| first_indexed | 2024-12-21T03:15:34Z |
| format | Article |
| id | doaj.art-aedfd0c2bc1e4da4a8afde5e81276911 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-12-21T03:15:34Z |
| publishDate | 2022-01-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-aedfd0c2bc1e4da4a8afde5e812769112022-12-21T19:17:52ZengEuropean Respiratory SocietyERJ Open Research2312-05412022-01-018110.1183/23120541.00429-202100429-2021The risk of respiratory tract infections and antibiotic use in a general population and among people with asthmaMarta A. Kisiel0Xingwu Zhou1Eythor Björnsson2Mathias Holm3Anna Dahlman-Höglund4Juan Wang5Cecilie Svanes6Dan Norbäck7Karl A. Franklin8Andrei Malinovschi9Ane Johannessen10Vivi Schlünssen11Christer Janson12 Dept of Medical Sciences: Environmental and Occupational Medicine, Uppsala University, Uppsala, Sweden Dept of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden Reykjalundur Rehabilitation Hospital, Mosfellsbær, Iceland Section of Occupational and Environmental Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Section of Occupational and Environmental Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Dept of Medical Sciences: Environmental and Occupational Medicine, Uppsala University, Uppsala, Sweden Dept of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway Dept of Medical Sciences: Environmental and Occupational Medicine, Uppsala University, Uppsala, Sweden Dept of Surgical and Perioperative Sciences, Surgery, Umeå University, Umeå, Sweden Dept of Medical Sciences: Clinical Physiology, Uppsala University, Uppsala, Sweden Dept of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway Dept of Public Health, Danish Ramazzini Centre, Aarhus University and the National Research Centre for the Working Environment, Copenhagen, Denmark Dept of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden Aim The aim of this study was to investigate occupational, environmental, early life and other risk factors associated with respiratory infections and antibiotics use in a general population and among asthmatic individuals. Method This study included 15 842 participants of the Respiratory Health in Northern Europe (RHINE) study aged 25–54 years from five Nordic countries, who answered a questionnaire covering respiratory outcomes, exposures, demographic characteristics and numbers of infections and courses of antibiotics in the last 12 months. Multiple logistic regression with and without adjustment for age, sex, smoking status, body mass index and centre were used to study the risk of infection and antibiotics in relation to asthma, and also the association between infection and antibiotics and occupations. Results In the whole population, 11.6% reported having three or more respiratory infections, and 14.7% had used antibiotics because of respiratory tract infections within the last year. Asthmatic participants reported tripled odds for such infections (adjusted OR 2.98, 95% CI 2.53–3.52) and antibiotics use (adjusted OR 3.67, 95% CI 3.18–4.24) as compared to non-asthmatic participants. Both in the general and the asthmatic population, female sex, obesity and exposure to building dampness were associated with respiratory infections. Female sex and current smoking and living in Tartu were associated with antibiotic use. The use of antibiotics was doubled in people hospitalised for severe respiratory infection in childhood. Conclusion In this study we identified several factors associated with increased respiratory infections and use of antibiotics in a general population and among asthmatic individuals. The frequency of respiratory infections and subsequent antibiotic treatment were increased among those with asthma.http://openres.ersjournals.com/content/8/1/00429-2021.full |
| spellingShingle | Marta A. Kisiel Xingwu Zhou Eythor Björnsson Mathias Holm Anna Dahlman-Höglund Juan Wang Cecilie Svanes Dan Norbäck Karl A. Franklin Andrei Malinovschi Ane Johannessen Vivi Schlünssen Christer Janson The risk of respiratory tract infections and antibiotic use in a general population and among people with asthma ERJ Open Research |
| title | The risk of respiratory tract infections and antibiotic use in a general population and among people with asthma |
| title_full | The risk of respiratory tract infections and antibiotic use in a general population and among people with asthma |
| title_fullStr | The risk of respiratory tract infections and antibiotic use in a general population and among people with asthma |
| title_full_unstemmed | The risk of respiratory tract infections and antibiotic use in a general population and among people with asthma |
| title_short | The risk of respiratory tract infections and antibiotic use in a general population and among people with asthma |
| title_sort | risk of respiratory tract infections and antibiotic use in a general population and among people with asthma |
| url | http://openres.ersjournals.com/content/8/1/00429-2021.full |
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