The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases
Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to che...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/1/106 |
| _version_ | 1797496255640764416 |
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| author | Camino San Martin Ruano Francisco Miralles Céline Méhats Daniel Vaiman |
| author_facet | Camino San Martin Ruano Francisco Miralles Céline Méhats Daniel Vaiman |
| author_sort | Camino San Martin Ruano |
| collection | DOAJ |
| description | Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta. |
| first_indexed | 2024-03-10T03:01:02Z |
| format | Article |
| id | doaj.art-aee0a4c4039a4e65a7a7f1462028170c |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:01:02Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-aee0a4c4039a4e65a7a7f1462028170c2023-11-23T12:47:25ZengMDPI AGAntioxidants2076-39212022-01-0111110610.3390/antiox11010106The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental DiseasesCamino San Martin Ruano0Francisco Miralles1Céline Méhats2Daniel Vaiman3Institut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, FranceInstitut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, FranceInstitut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, FranceInstitut Cochin Departement Development Reproduction Cancer, U1016 INSERM, UMR8104 CNRS, Université de Paris, 24 Rue du Faubourg St Jacques, 75014 Paris, FranceOxidative stress (OS) plays a pivotal role in placental development; however, abnormal loads in oxidative stress molecules may overwhelm the placental defense mechanisms and cause pathological situations. The environment in which the mother evolves triggers an exposure of the placental tissue to chemical, physical, and biological agents of OS, with potential pathological consequences. Here we shortly review the physiological and developmental functions of OS in the placenta, and present a series of environmental pollutants inducing placental oxidative stress, for which some insights regarding the underlying mechanisms have been proposed, leading to a recapitulation of the noxious effects of OS of environmental origin upon the human placenta.https://www.mdpi.com/2076-3921/11/1/106environmental pollutionplacentaheavy metalsP38MAPKDNA methylationplacental diseases |
| spellingShingle | Camino San Martin Ruano Francisco Miralles Céline Méhats Daniel Vaiman The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases Antioxidants environmental pollution placenta heavy metals P38MAPK DNA methylation placental diseases |
| title | The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases |
| title_full | The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases |
| title_fullStr | The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases |
| title_full_unstemmed | The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases |
| title_short | The Impact of Oxidative Stress of Environmental Origin on the Onset of Placental Diseases |
| title_sort | impact of oxidative stress of environmental origin on the onset of placental diseases |
| topic | environmental pollution placenta heavy metals P38MAPK DNA methylation placental diseases |
| url | https://www.mdpi.com/2076-3921/11/1/106 |
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