Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Abstract Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic methodologies, it is now possible to study TME’s individual components and their i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-022-00866-3 |
| _version_ | 1828140585090809856 |
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| author | Aadhya Tiwari Rakesh Trivedi Shiaw-Yih Lin |
| author_facet | Aadhya Tiwari Rakesh Trivedi Shiaw-Yih Lin |
| author_sort | Aadhya Tiwari |
| collection | DOAJ |
| description | Abstract Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic methodologies, it is now possible to study TME’s individual components and their interplay at higher resolution. Deeper understanding of the immune cell’s diversity, stromal constituents, repertoire profiling, neoantigen prediction of TMEs has provided the opportunity to explore the spatial and temporal regulation of immune therapeutic interventions. The variation of TME composition among patients plays an important role in determining responders and non-responders towards cancer immunotherapy. Therefore, there could be a possibility of reprogramming of TME components to overcome the widely prevailing issue of immunotherapeutic resistance. The focus of the present review is to understand the complexity of TME and comprehending future perspective of its components as potential therapeutic targets. The later part of the review describes the sophisticated 3D models emerging as valuable means to study TME components and an extensive account of advanced bioinformatic tools to profile TME components and predict neoantigens. Overall, this review provides a comprehensive account of the current knowledge available to target TME. |
| first_indexed | 2024-04-11T19:12:05Z |
| format | Article |
| id | doaj.art-aee1c96d1da643cd91f93c643268be3c |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-04-11T19:12:05Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-aee1c96d1da643cd91f93c643268be3c2022-12-22T04:07:36ZengBMCJournal of Biomedical Science1423-01272022-10-0129112710.1186/s12929-022-00866-3Tumor microenvironment: barrier or opportunity towards effective cancer therapyAadhya Tiwari0Rakesh Trivedi1Shiaw-Yih Lin2Department of Systems Biology, The University of Texas MD Anderson Cancer CenterDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer CenterDepartment of Systems Biology, The University of Texas MD Anderson Cancer CenterAbstract Tumor microenvironment (TME) is a specialized ecosystem of host components, designed by tumor cells for successful development and metastasis of tumor. With the advent of 3D culture and advanced bioinformatic methodologies, it is now possible to study TME’s individual components and their interplay at higher resolution. Deeper understanding of the immune cell’s diversity, stromal constituents, repertoire profiling, neoantigen prediction of TMEs has provided the opportunity to explore the spatial and temporal regulation of immune therapeutic interventions. The variation of TME composition among patients plays an important role in determining responders and non-responders towards cancer immunotherapy. Therefore, there could be a possibility of reprogramming of TME components to overcome the widely prevailing issue of immunotherapeutic resistance. The focus of the present review is to understand the complexity of TME and comprehending future perspective of its components as potential therapeutic targets. The later part of the review describes the sophisticated 3D models emerging as valuable means to study TME components and an extensive account of advanced bioinformatic tools to profile TME components and predict neoantigens. Overall, this review provides a comprehensive account of the current knowledge available to target TME.https://doi.org/10.1186/s12929-022-00866-3Tumor microenvironmentCancer immunotherapy3D modelsCheckpoint inhibitorsSpecialized microenvironmentTME profiling |
| spellingShingle | Aadhya Tiwari Rakesh Trivedi Shiaw-Yih Lin Tumor microenvironment: barrier or opportunity towards effective cancer therapy Journal of Biomedical Science Tumor microenvironment Cancer immunotherapy 3D models Checkpoint inhibitors Specialized microenvironment TME profiling |
| title | Tumor microenvironment: barrier or opportunity towards effective cancer therapy |
| title_full | Tumor microenvironment: barrier or opportunity towards effective cancer therapy |
| title_fullStr | Tumor microenvironment: barrier or opportunity towards effective cancer therapy |
| title_full_unstemmed | Tumor microenvironment: barrier or opportunity towards effective cancer therapy |
| title_short | Tumor microenvironment: barrier or opportunity towards effective cancer therapy |
| title_sort | tumor microenvironment barrier or opportunity towards effective cancer therapy |
| topic | Tumor microenvironment Cancer immunotherapy 3D models Checkpoint inhibitors Specialized microenvironment TME profiling |
| url | https://doi.org/10.1186/s12929-022-00866-3 |
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