Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis
(1) Background: Somatic mutations may be connected to the exposome, potentially playing a role in breast cancer’s development and clinical outcomes. There needs to be information regarding Latin American women specifically, as they are underrepresented in clinical trials and have limited access to s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/14/3/287 |
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| author | Gabriela A. Martínez-Nava Laura Keren Urbina-Jara Saúl Lira-Albarrán Henry L. Gómez Erika Ruiz-García María Tereza Nieto-Coronel Rocio Ortiz-Lopez Kenia Nadiezhda Martínez Villalba Mariana Muñoz-Sánchez Dione Aguilar Liliana Gómez-Flores-Ramos Sara Aileen Cabrera-Nieto Alejandro Mohar Marlid Cruz-Ramos |
| author_facet | Gabriela A. Martínez-Nava Laura Keren Urbina-Jara Saúl Lira-Albarrán Henry L. Gómez Erika Ruiz-García María Tereza Nieto-Coronel Rocio Ortiz-Lopez Kenia Nadiezhda Martínez Villalba Mariana Muñoz-Sánchez Dione Aguilar Liliana Gómez-Flores-Ramos Sara Aileen Cabrera-Nieto Alejandro Mohar Marlid Cruz-Ramos |
| author_sort | Gabriela A. Martínez-Nava |
| collection | DOAJ |
| description | (1) Background: Somatic mutations may be connected to the exposome, potentially playing a role in breast cancer’s development and clinical outcomes. There needs to be information regarding Latin American women specifically, as they are underrepresented in clinical trials and have limited access to somatic analysis in their countries. This study aims to systematically investigate somatic mutations in breast cancer patients from Latin America to gain a better understanding of tumor biology in the region. (2) Methods: We realize a systematic review of studies on breast cancer in 21 Latin American countries using various databases such as PubMed, Google Scholar, Web of Science, RedAlyc, Dianlet, and Biblioteca Virtual en Salud. Of 392 articles that fit the criteria, 10 studies have clinical data which can be used to create a database containing clinical and genetic information. We compared mutation frequencies across different breast cancer subtypes using statistical analyses and meta-analyses of proportions. Furthermore, we identified overexpressed biological processes and canonical pathways through functional enrichment analysis. (3) Results: 342 mutations were found in six Latin American countries, with the <i>TP53</i> and <i>PIK3CA</i> genes being the most studied mutations. The most common <i>PIK3CA</i> mutation was H1047R. Functional analysis provided insights into tumor biology and potential therapies. (4) Conclusion: evaluating specific somatic mutations in the Latin American population is crucial for understanding tumor biology and determining appropriate treatment options. Combining targeted therapies may improve clinical outcomes in breast cancer. Moreover, implementing healthy lifestyle strategies in Latin America could enhance therapy effectiveness and clinical outcomes. |
| first_indexed | 2024-03-08T03:58:53Z |
| format | Article |
| id | doaj.art-aee219012be2473393696d15261d309e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T03:58:53Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-aee219012be2473393696d15261d309e2024-02-09T15:10:06ZengMDPI AGDiagnostics2075-44182024-01-0114328710.3390/diagnostics14030287Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-AnalysisGabriela A. Martínez-Nava0Laura Keren Urbina-Jara1Saúl Lira-Albarrán2Henry L. Gómez3Erika Ruiz-García4María Tereza Nieto-Coronel5Rocio Ortiz-Lopez6Kenia Nadiezhda Martínez Villalba7Mariana Muñoz-Sánchez8Dione Aguilar9Liliana Gómez-Flores-Ramos10Sara Aileen Cabrera-Nieto11Alejandro Mohar12Marlid Cruz-Ramos13Laboratorio de Gerociencias, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Calz. México-Xochimilco 289, Tlalpan, Mexico City 14389, MexicoTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, MexicoDepartamento de Gestión Académica e Investigación, Hospital Escuela, Tegucigalpa 11101, HondurasDepartmento de Medicina Oncológica, Instituto Nacional de Enfermedades Neoplásicas, Av. Angamos Este 2520, Lima 15023, PeruLaboratorio de Medicina Traslacional, Instituto Nacional de Cancerologia, Mexico City 14080, MexicoDepartamento de Medicina Oncológica, Centro Oncopalia, Universidad Mayor de San Andrés, La Paz P.O. Box 8635, BoliviaTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey 64710, MexicoUnidad de Epidemiología e Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, UNAM-Instituto Nacional de Cancerología, Mexico City 14080, MexicoFacultad de Ciencias de la Salud, Universidad Anáhuac México, Mexico City 52786, MexicoTecnologico de Monterrey, Centro de Cáncer de Mama, Hospital Zambrano Hellion, San Pedro Garza García 66278, MexicoCONAHCYT/Center for Population Health Research, National Institute of Public Health, Universidad No. 655, Cuernavaca 62100, MexicoFacultad de Ciencias de la Salud, Universidad Anáhuac México, Mexico City 52786, MexicoUnidad de Epidemiología e Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, UNAM-Instituto Nacional de Cancerología, Mexico City 14080, MexicoPrograma Joven y Fuerte/CONAHCYT, Instituto Nacional de Cancerología, Av. San Fernando 22, Belisario Domínguez Sección 16, Tlalpan, Mexico City 14080, Mexico(1) Background: Somatic mutations may be connected to the exposome, potentially playing a role in breast cancer’s development and clinical outcomes. There needs to be information regarding Latin American women specifically, as they are underrepresented in clinical trials and have limited access to somatic analysis in their countries. This study aims to systematically investigate somatic mutations in breast cancer patients from Latin America to gain a better understanding of tumor biology in the region. (2) Methods: We realize a systematic review of studies on breast cancer in 21 Latin American countries using various databases such as PubMed, Google Scholar, Web of Science, RedAlyc, Dianlet, and Biblioteca Virtual en Salud. Of 392 articles that fit the criteria, 10 studies have clinical data which can be used to create a database containing clinical and genetic information. We compared mutation frequencies across different breast cancer subtypes using statistical analyses and meta-analyses of proportions. Furthermore, we identified overexpressed biological processes and canonical pathways through functional enrichment analysis. (3) Results: 342 mutations were found in six Latin American countries, with the <i>TP53</i> and <i>PIK3CA</i> genes being the most studied mutations. The most common <i>PIK3CA</i> mutation was H1047R. Functional analysis provided insights into tumor biology and potential therapies. (4) Conclusion: evaluating specific somatic mutations in the Latin American population is crucial for understanding tumor biology and determining appropriate treatment options. Combining targeted therapies may improve clinical outcomes in breast cancer. Moreover, implementing healthy lifestyle strategies in Latin America could enhance therapy effectiveness and clinical outcomes.https://www.mdpi.com/2075-4418/14/3/287breast cancersomatic mutationexposometarget therapyLatin America |
| spellingShingle | Gabriela A. Martínez-Nava Laura Keren Urbina-Jara Saúl Lira-Albarrán Henry L. Gómez Erika Ruiz-García María Tereza Nieto-Coronel Rocio Ortiz-Lopez Kenia Nadiezhda Martínez Villalba Mariana Muñoz-Sánchez Dione Aguilar Liliana Gómez-Flores-Ramos Sara Aileen Cabrera-Nieto Alejandro Mohar Marlid Cruz-Ramos Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis Diagnostics breast cancer somatic mutation exposome target therapy Latin America |
| title | Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis |
| title_full | Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis |
| title_short | Somatic Mutations in Latin American Breast Cancer Patients: A Systematic Review and Meta-Analysis |
| title_sort | somatic mutations in latin american breast cancer patients a systematic review and meta analysis |
| topic | breast cancer somatic mutation exposome target therapy Latin America |
| url | https://www.mdpi.com/2075-4418/14/3/287 |
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