Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study
Antidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registry study to assess antidepressant non-adherence during 2021 ha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2696 |
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| author | M. Aránzazu Pedrosa-Naudín Eduardo Gutiérrez-Abejón Francisco Herrera-Gómez Diego Fernández-Lázaro F. Javier Álvarez |
| author_facet | M. Aránzazu Pedrosa-Naudín Eduardo Gutiérrez-Abejón Francisco Herrera-Gómez Diego Fernández-Lázaro F. Javier Álvarez |
| author_sort | M. Aránzazu Pedrosa-Naudín |
| collection | DOAJ |
| description | Antidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registry study to assess antidepressant non-adherence during 2021 has been carried out. An indirect method based on the medication possession ratio (MPR) has been utilized. Patients with a MPR under 80% were classified as non-adherent. A multivariate logistic regression to identify non-adherence predictors has been used, considering sociodemographic (age, sex, institutionalization and urbanicity) and health related variables (diagnostics, antidepressant class, multiple prescribers, and polypharmacy). In 2021, 10.6% of the Castile and Leon population used antidepressants. These patients were institutionalized (7.29%), living in urban areas (63.44%), polymedicated with multiple prescribers (57.07%), and using serotonin selective reuptake inhibitors (SSRIs) (54.77%), other antidepressants (46.82%) or tricyclic antidepressants (TCAs) (13.76%). Antidepressants were prescribed mainly for depression (36.73%) and anxiety (29.24%). Non-adherence to antidepressants was more frequent in men (20.56%) than in woman (19.59%) and decreased with increasing age (32% up to 17 years old vs. 13.76% over 80 years old). TCAs were associated with the highest prevalence of non-adherence (23.99%), followed by SSRIs (20.19%) and other antidepressants (18.5%). Predictors of non-adherence in patients on antidepressants were: living in urban areas, using TCAs, and pain occurrence. Non-adherence to antidepressants decreases with aging. Being female, institutionalization, being polymedicated and having depression/anxiety alongside another psychiatric diagnosis are protective factors against non-adherence. The MPR is a robust indicator for the clinician to identify non-adherent patients for monitoring, and adopt any necessary corrective actions. |
| first_indexed | 2024-03-09T15:58:38Z |
| format | Article |
| id | doaj.art-aee26717d6fa4f78bd20dc140cc603dc |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:38Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-aee26717d6fa4f78bd20dc140cc603dc2023-11-24T17:20:26ZengMDPI AGPharmaceutics1999-49232022-12-011412269610.3390/pharmaceutics14122696Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry StudyM. Aránzazu Pedrosa-Naudín0Eduardo Gutiérrez-Abejón1Francisco Herrera-Gómez2Diego Fernández-Lázaro3F. Javier Álvarez4Pharmacy Directorate, Castilla y León Health Council, 47007 Valladolid, SpainPharmacy Directorate, Castilla y León Health Council, 47007 Valladolid, SpainPharmacological Big Data Laboratory, Faculty of Medicine, University of Valladolid, 47005 Valladolid, SpainDepartment of Cellular Biology, Histology and Pharmacology, Faculty of Health Sciences, Campus of Soria, University of Valladolid, 42003 Soria, SpainPharmacological Big Data Laboratory, Faculty of Medicine, University of Valladolid, 47005 Valladolid, SpainAntidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registry study to assess antidepressant non-adherence during 2021 has been carried out. An indirect method based on the medication possession ratio (MPR) has been utilized. Patients with a MPR under 80% were classified as non-adherent. A multivariate logistic regression to identify non-adherence predictors has been used, considering sociodemographic (age, sex, institutionalization and urbanicity) and health related variables (diagnostics, antidepressant class, multiple prescribers, and polypharmacy). In 2021, 10.6% of the Castile and Leon population used antidepressants. These patients were institutionalized (7.29%), living in urban areas (63.44%), polymedicated with multiple prescribers (57.07%), and using serotonin selective reuptake inhibitors (SSRIs) (54.77%), other antidepressants (46.82%) or tricyclic antidepressants (TCAs) (13.76%). Antidepressants were prescribed mainly for depression (36.73%) and anxiety (29.24%). Non-adherence to antidepressants was more frequent in men (20.56%) than in woman (19.59%) and decreased with increasing age (32% up to 17 years old vs. 13.76% over 80 years old). TCAs were associated with the highest prevalence of non-adherence (23.99%), followed by SSRIs (20.19%) and other antidepressants (18.5%). Predictors of non-adherence in patients on antidepressants were: living in urban areas, using TCAs, and pain occurrence. Non-adherence to antidepressants decreases with aging. Being female, institutionalization, being polymedicated and having depression/anxiety alongside another psychiatric diagnosis are protective factors against non-adherence. The MPR is a robust indicator for the clinician to identify non-adherent patients for monitoring, and adopt any necessary corrective actions.https://www.mdpi.com/1999-4923/14/12/2696antidepressantsmedication adherencedrug utilizationpolypharmacydepressionanxiety |
| spellingShingle | M. Aránzazu Pedrosa-Naudín Eduardo Gutiérrez-Abejón Francisco Herrera-Gómez Diego Fernández-Lázaro F. Javier Álvarez Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study Pharmaceutics antidepressants medication adherence drug utilization polypharmacy depression anxiety |
| title | Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study |
| title_full | Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study |
| title_fullStr | Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study |
| title_full_unstemmed | Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study |
| title_short | Non-Adherence to Antidepressant Treatment and Related Factors in a Region of Spain: A Population-Based Registry Study |
| title_sort | non adherence to antidepressant treatment and related factors in a region of spain a population based registry study |
| topic | antidepressants medication adherence drug utilization polypharmacy depression anxiety |
| url | https://www.mdpi.com/1999-4923/14/12/2696 |
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