Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion

Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion

Complement synthesis in cells of origin is strongly linked to the pathogenesis and progression of renal disease. Multiple studies have examined local C3 synthesis in renal disease and elucidated the contribution of local cellular sources, but the contribution of infiltrating inflammatory cells remai...

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Bibliographic Details
Main Authors: Yanyan Liu, Kun Wang, Xinjun Liang, Yueqiang Li, Ying Zhang, Chunxiu Zhang, Haotian Wei, Ran Luo, Shuwang Ge, Gang Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
complement component 3
macrophage
renal fibrosis (RF)
IL-17A
IgAN
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02385/full

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