Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants
Individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2009-01-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400010 |
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| author | Marcos Euzébio Maciel Fausto Koga Oliveira Gustavo Bonfim Propst Maria da Graça Bicalho Iglenir João Cavalli Enilze Maria de Souza Fonseca Ribeiro |
| author_facet | Marcos Euzébio Maciel Fausto Koga Oliveira Gustavo Bonfim Propst Maria da Graça Bicalho Iglenir João Cavalli Enilze Maria de Souza Fonseca Ribeiro |
| author_sort | Marcos Euzébio Maciel |
| collection | DOAJ |
| description | Individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation of the results difficult. We sought to estimate population parameters for the cytochrome P450 and glutathione S-transferase gene families, thus contributing to studies using these genes as markers. We describe the frequencies of six genes (CYP1A1, CYP2D6, CYP2E1, GSTM1, GSTT1, and GSTP1) and estimate population parameters in 115 Euro-descendants and 196 Afro-descendants from Curitiba, South of Brazil. PCR-based methods were used for genotyping, and statistical analysis were performed by AMOVA with ARLEQUIN software. The mutant allele frequencies in the Afro-descendants and Euro-descendants, respectively, were: CYP1A1*2A = 30.1% and 15.2%; CYP2D6*4 = 14.5% and 21.5%; CYP2E1*5B = 7.9% and 5%; GSTP1*B = 37.8% and 28.3%. The null genotype frequencies were: GSTM1*0 = 36.8% and 46.1%; GSTT1*0 = 24.2% and 17.4%. |
| first_indexed | 2024-12-19T16:42:32Z |
| format | Article |
| id | doaj.art-aee438ef73c54d108697d31e32a2c081 |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-19T16:42:32Z |
| publishDate | 2009-01-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-aee438ef73c54d108697d31e32a2c0812022-12-21T20:13:45ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-46852009-01-01324723728Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendantsMarcos Euzébio MacielFausto Koga OliveiraGustavo Bonfim PropstMaria da Graça BicalhoIglenir João CavalliEnilze Maria de Souza Fonseca RibeiroIndividual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation of the results difficult. We sought to estimate population parameters for the cytochrome P450 and glutathione S-transferase gene families, thus contributing to studies using these genes as markers. We describe the frequencies of six genes (CYP1A1, CYP2D6, CYP2E1, GSTM1, GSTT1, and GSTP1) and estimate population parameters in 115 Euro-descendants and 196 Afro-descendants from Curitiba, South of Brazil. PCR-based methods were used for genotyping, and statistical analysis were performed by AMOVA with ARLEQUIN software. The mutant allele frequencies in the Afro-descendants and Euro-descendants, respectively, were: CYP1A1*2A = 30.1% and 15.2%; CYP2D6*4 = 14.5% and 21.5%; CYP2E1*5B = 7.9% and 5%; GSTP1*B = 37.8% and 28.3%. The null genotype frequencies were: GSTM1*0 = 36.8% and 46.1%; GSTT1*0 = 24.2% and 17.4%.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400010CYPGSTpopulation study |
| spellingShingle | Marcos Euzébio Maciel Fausto Koga Oliveira Gustavo Bonfim Propst Maria da Graça Bicalho Iglenir João Cavalli Enilze Maria de Souza Fonseca Ribeiro Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants Genetics and Molecular Biology CYP GST population study |
| title | Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants |
| title_full | Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants |
| title_fullStr | Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants |
| title_full_unstemmed | Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants |
| title_short | Population analysis of xenobiotic metabolizing genes in South Brazilian Euro and Afro-descendants |
| title_sort | population analysis of xenobiotic metabolizing genes in south brazilian euro and afro descendants |
| topic | CYP GST population study |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000400010 |
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