Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study
Abstract Background Neurological symptoms are frequent among patients with COVID-19. Little is known regarding the repercussions of neurological symptoms for patients and how these symptoms are related to one another. Objectives To determine whether there is an association between the neurological s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | The Journal of Headache and Pain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10194-021-01367-8 |
| _version_ | 1798034665946218496 |
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| author | Pedro Augusto Sampaio Rocha-Filho Pedro Mota Albuquerque Larissa Clementino Leite Sá Carvalho Mylana Dandara Pereira Gama João Eudes Magalhães |
| author_facet | Pedro Augusto Sampaio Rocha-Filho Pedro Mota Albuquerque Larissa Clementino Leite Sá Carvalho Mylana Dandara Pereira Gama João Eudes Magalhães |
| author_sort | Pedro Augusto Sampaio Rocha-Filho |
| collection | DOAJ |
| description | Abstract Background Neurological symptoms are frequent among patients with COVID-19. Little is known regarding the repercussions of neurological symptoms for patients and how these symptoms are related to one another. Objectives To determine whether there is an association between the neurological symptoms in patients with COVID-19, and to characterize the headache. Method This was a cross-sectional study. All hospital inpatients and health workers at the Hospital Universitario Oswaldo Cruz with a PCR-confirmed COVID-19 infection between March and June 2020 were considered for the study and were interviewed by telephone at least 2-months after the acute phase of the disease. These patients were identified by the hospital epidemiological surveillance department. A semi-structured questionnaire was used containing sociodemographic and clinical data and the ID-Migraine. Results A total of 288 patients was interviewed; 53.1% were male; with a median age of 49.9 (41.5–60.5) years; 91.7% presented some neurological symptom; 22.2% reported some neurological symptom as the symptom that troubled them most during COVID-19. Neurological symptoms were: ageusia (69.8%), headache (69.1%), anosmia (67%), myalgia (44.4%), drowsiness (37.2%), agitation (20.8%); mental confusion (14.9%), syncope (4.9%) and epileptic seizures (2.8%). Females, those who presented with fever, sore throat, anosmia/ageusia and myalgia also presented significantly more with headache (logistic regression). The most frequent headache phenotype was a non-migraine phenotype, was of severe intensity and differed from previous headaches. This persisted for more than 30 days in 18% and for more than 90 days in 10% of patients. Thirteen percent of those with anosmia and 11% with ageusia continued with these complaints after more than 90 days of the acute phase of the disease. Aged over 50 years, agitation and epileptic seizures were significantly associated with mental confusion (logistic regression). Conclusion Headache is frequent in COVID-19, is associated with other symptoms such as fever, sore throat, anosmia, ageusia, and myalgia, and may persist beyond the acute phase of the disease. |
| first_indexed | 2024-04-11T20:47:27Z |
| format | Article |
| id | doaj.art-aee6a63ef98f41a6aec8dff6133d3d45 |
| institution | Directory Open Access Journal |
| issn | 1129-2369 1129-2377 |
| language | English |
| last_indexed | 2024-04-11T20:47:27Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj.art-aee6a63ef98f41a6aec8dff6133d3d452022-12-22T04:03:58ZengBMCThe Journal of Headache and Pain1129-23691129-23772022-01-0123111110.1186/s10194-021-01367-8Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional studyPedro Augusto Sampaio Rocha-Filho0Pedro Mota Albuquerque1Larissa Clementino Leite Sá Carvalho2Mylana Dandara Pereira Gama3João Eudes Magalhães4Division of Neuropsychiatry, Centro de Ciências Médicas, Universidade Federal de Pernambuco (UFPE)Division of Neuropsychiatry, Centro de Ciências Médicas, Universidade Federal de Pernambuco (UFPE)Hospital Universitario Oswaldo Cruz, Universidade de PernambucoHospital Universitario Oswaldo Cruz, Universidade de PernambucoHospital Universitario Oswaldo Cruz, Universidade de PernambucoAbstract Background Neurological symptoms are frequent among patients with COVID-19. Little is known regarding the repercussions of neurological symptoms for patients and how these symptoms are related to one another. Objectives To determine whether there is an association between the neurological symptoms in patients with COVID-19, and to characterize the headache. Method This was a cross-sectional study. All hospital inpatients and health workers at the Hospital Universitario Oswaldo Cruz with a PCR-confirmed COVID-19 infection between March and June 2020 were considered for the study and were interviewed by telephone at least 2-months after the acute phase of the disease. These patients were identified by the hospital epidemiological surveillance department. A semi-structured questionnaire was used containing sociodemographic and clinical data and the ID-Migraine. Results A total of 288 patients was interviewed; 53.1% were male; with a median age of 49.9 (41.5–60.5) years; 91.7% presented some neurological symptom; 22.2% reported some neurological symptom as the symptom that troubled them most during COVID-19. Neurological symptoms were: ageusia (69.8%), headache (69.1%), anosmia (67%), myalgia (44.4%), drowsiness (37.2%), agitation (20.8%); mental confusion (14.9%), syncope (4.9%) and epileptic seizures (2.8%). Females, those who presented with fever, sore throat, anosmia/ageusia and myalgia also presented significantly more with headache (logistic regression). The most frequent headache phenotype was a non-migraine phenotype, was of severe intensity and differed from previous headaches. This persisted for more than 30 days in 18% and for more than 90 days in 10% of patients. Thirteen percent of those with anosmia and 11% with ageusia continued with these complaints after more than 90 days of the acute phase of the disease. Aged over 50 years, agitation and epileptic seizures were significantly associated with mental confusion (logistic regression). Conclusion Headache is frequent in COVID-19, is associated with other symptoms such as fever, sore throat, anosmia, ageusia, and myalgia, and may persist beyond the acute phase of the disease.https://doi.org/10.1186/s10194-021-01367-8Neurologic manifestationsCOVID-19SARS-CoV-2HeadacheAnosmiaAgeusia |
| spellingShingle | Pedro Augusto Sampaio Rocha-Filho Pedro Mota Albuquerque Larissa Clementino Leite Sá Carvalho Mylana Dandara Pereira Gama João Eudes Magalhães Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study The Journal of Headache and Pain Neurologic manifestations COVID-19 SARS-CoV-2 Headache Anosmia Ageusia |
| title | Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study |
| title_full | Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study |
| title_fullStr | Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study |
| title_full_unstemmed | Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study |
| title_short | Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study |
| title_sort | headache anosmia ageusia and other neurological symptoms in covid 19 a cross sectional study |
| topic | Neurologic manifestations COVID-19 SARS-CoV-2 Headache Anosmia Ageusia |
| url | https://doi.org/10.1186/s10194-021-01367-8 |
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