Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review
Background: Liposarcoma (LPS) is the second most common type of soft tissue sarcoma, accounting for approximately 15–20% of all the sarcomas. Primary intrathoracic LPS, however, is quite rare. LPS is a malignant mesenchymal tumor, comprised of lipogenic tissue with varying degrees of atypia. It can...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007118303198 |
| _version_ | 1828855757137772544 |
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| author | Umair Ashraf Rizwan Ahmed Dudekula Swathi Roy Joshua Burack Sandeep Malik Misbahuddin Khaja |
| author_facet | Umair Ashraf Rizwan Ahmed Dudekula Swathi Roy Joshua Burack Sandeep Malik Misbahuddin Khaja |
| author_sort | Umair Ashraf |
| collection | DOAJ |
| description | Background: Liposarcoma (LPS) is the second most common type of soft tissue sarcoma, accounting for approximately 15–20% of all the sarcomas. Primary intrathoracic LPS, however, is quite rare. LPS is a malignant mesenchymal tumor, comprised of lipogenic tissue with varying degrees of atypia. It can be subclassified into well-differentiated LPS (WDLPS), myxoid LPS (MLPS)/round cell LPS, pleomorphic LPS (PLPs), and dedifferentiated LPS (DDLPS), based on the histology. Case presentation: A 76-year-old male patient initially presented to the emergency room with a complaint of precordial chest pain for one month. Computed tomography (CT) of his chest showed a large, 8 cm × 8 cm x 10 cm, supradiaphragmatic, complex solid mass in the lower left hemithorax, along the anterior chest wall. Chest wall mass excision revealed dedifferentiated LPS, with excision of margins. Positron emission tomography (PET) scan did not show metastatic disease. Seven months later, he presented with shortness of breath, and CT of the chest showed large, left pleural-based masses, causing compression of surrounding structures. He was not a candidate for surgical resection. This patient subsequently failed chemotherapy and opted for hospice. Conclusion: Intrathoracic LPS is a rare tumor. Recurrence is higher with dedifferentiated histology forms. Radical surgery with excision of margins is the primary recommended treatment. Keywords: Liposarcoma, Intrathoracic tumors, Soft tissue sarcoma |
| first_indexed | 2024-12-13T01:00:37Z |
| format | Article |
| id | doaj.art-aee76aa805154accaa92e17b97fedf54 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-13T01:00:37Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-aee76aa805154accaa92e17b97fedf542022-12-22T00:04:41ZengElsevierRespiratory Medicine Case Reports2213-00712019-01-0126281284Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature reviewUmair Ashraf0Rizwan Ahmed Dudekula1Swathi Roy2Joshua Burack3Sandeep Malik4Misbahuddin Khaja5Division of Pulmonary and Critical Care Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USADivision of Pulmonary and Critical Care Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Surgery, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USADivision of Hematology and Oncology, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USADivision of Pulmonary and Critical Care Medicine, Bronx Care Health System, Affiliated with Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY 10457, USA; Corresponding author.Background: Liposarcoma (LPS) is the second most common type of soft tissue sarcoma, accounting for approximately 15–20% of all the sarcomas. Primary intrathoracic LPS, however, is quite rare. LPS is a malignant mesenchymal tumor, comprised of lipogenic tissue with varying degrees of atypia. It can be subclassified into well-differentiated LPS (WDLPS), myxoid LPS (MLPS)/round cell LPS, pleomorphic LPS (PLPs), and dedifferentiated LPS (DDLPS), based on the histology. Case presentation: A 76-year-old male patient initially presented to the emergency room with a complaint of precordial chest pain for one month. Computed tomography (CT) of his chest showed a large, 8 cm × 8 cm x 10 cm, supradiaphragmatic, complex solid mass in the lower left hemithorax, along the anterior chest wall. Chest wall mass excision revealed dedifferentiated LPS, with excision of margins. Positron emission tomography (PET) scan did not show metastatic disease. Seven months later, he presented with shortness of breath, and CT of the chest showed large, left pleural-based masses, causing compression of surrounding structures. He was not a candidate for surgical resection. This patient subsequently failed chemotherapy and opted for hospice. Conclusion: Intrathoracic LPS is a rare tumor. Recurrence is higher with dedifferentiated histology forms. Radical surgery with excision of margins is the primary recommended treatment. Keywords: Liposarcoma, Intrathoracic tumors, Soft tissue sarcomahttp://www.sciencedirect.com/science/article/pii/S2213007118303198 |
| spellingShingle | Umair Ashraf Rizwan Ahmed Dudekula Swathi Roy Joshua Burack Sandeep Malik Misbahuddin Khaja Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review Respiratory Medicine Case Reports |
| title | Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review |
| title_full | Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review |
| title_fullStr | Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review |
| title_full_unstemmed | Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review |
| title_short | Recurrent intrathoracic dedifferentiated liposarcoma: A case report and literature review |
| title_sort | recurrent intrathoracic dedifferentiated liposarcoma a case report and literature review |
| url | http://www.sciencedirect.com/science/article/pii/S2213007118303198 |
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