Outcome results in children with IgA nephropathy: a single center experience
Ipek Kaplan Bulut1, Sevgi Mir1, Betul Sozeri1, Mustafa Orhan Bulut2, Sait Sen3, Nida Dincel11Ege University Faculty of Medicine Department of Pediatric Nephrology, 2Ege University Faculty of Medicine Department of Pediatrics, Izmir, 3Ege University Faculty of Medicine Department of Pathology, Izmir,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2012-01-01
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| Series: | International Journal of Nephrology and Renovascular Disease |
| Online Access: | http://www.dovepress.com/outcome-results-in-children-with-iga-nephropathy-a-single-center-exper-a9104 |
| _version_ | 1811343827508658176 |
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| author | Kaplan Bulut I Mir S Sozeri B Bulut MO Sen S Dincel N |
| author_facet | Kaplan Bulut I Mir S Sozeri B Bulut MO Sen S Dincel N |
| author_sort | Kaplan Bulut I |
| collection | DOAJ |
| description | Ipek Kaplan Bulut1, Sevgi Mir1, Betul Sozeri1, Mustafa Orhan Bulut2, Sait Sen3, Nida Dincel11Ege University Faculty of Medicine Department of Pediatric Nephrology, 2Ege University Faculty of Medicine Department of Pediatrics, Izmir, 3Ege University Faculty of Medicine Department of Pathology, Izmir, TurkeyBackground: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis. Patients manifest variable clinical symptoms (eg, microhematuria) with preserved or progressive deterioration of renal function resulting in end-stage renal disease. The aim of this study was to evaluate patients from a single center to describe the clinical features, treatments, and follow-up results of those with the disease.Methods: This is a retrospective data study of all children with IgAN. Patients who had a histopathologically proven diagnosis of IgAN and were followed up for at least 5 years were included in the study. Renal biopsy, graded as Hass classification, was performed on all patients. A total of 39 patients were included in the study.Results: The mean follow-up time (± standard deviation) was 10.4 ± 3.51 (range 5–16) years. Twenty-nine patients (74.4%) were male and ten (25.6%) were female. Nineteen (48.7%) patients presented with recurrent macroscopic hematuria, ten (25.6%) with microscopic hematuria ± proteinuria, six (15.4%) with nephritic syndrome, and four (10.3%) with nephrotic syndrome. All patients underwent a renal biopsy, which was graded according to the Hass classification. At the end of follow-up time, 18 (46.1%) patients were normal, 15 (38.5%) had minor urinary abnormalities, three (7.7%) had active renal disease, and three (7.7%) developed renal failure.Conclusion: The results of the present study are better than those from most other series. The majority of children with IgAN in this study were admitted with recurrent macroscopic hematuria and found to have a good prognosis. We suggest that children with IgAN have a good prognosis in the first 5-year follow-up period.Keywords: immunoglobulin A nephropathy, childhood, prognosis |
| first_indexed | 2024-04-13T19:37:01Z |
| format | Article |
| id | doaj.art-aee7d9c5311948298e6e85e1bf6ed0a6 |
| institution | Directory Open Access Journal |
| issn | 1178-7058 |
| language | English |
| last_indexed | 2024-04-13T19:37:01Z |
| publishDate | 2012-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nephrology and Renovascular Disease |
| spelling | doaj.art-aee7d9c5311948298e6e85e1bf6ed0a62022-12-22T02:33:00ZengDove Medical PressInternational Journal of Nephrology and Renovascular Disease1178-70582012-01-012012default2328Outcome results in children with IgA nephropathy: a single center experienceKaplan Bulut IMir SSozeri BBulut MOSen SDincel NIpek Kaplan Bulut1, Sevgi Mir1, Betul Sozeri1, Mustafa Orhan Bulut2, Sait Sen3, Nida Dincel11Ege University Faculty of Medicine Department of Pediatric Nephrology, 2Ege University Faculty of Medicine Department of Pediatrics, Izmir, 3Ege University Faculty of Medicine Department of Pathology, Izmir, TurkeyBackground: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis. Patients manifest variable clinical symptoms (eg, microhematuria) with preserved or progressive deterioration of renal function resulting in end-stage renal disease. The aim of this study was to evaluate patients from a single center to describe the clinical features, treatments, and follow-up results of those with the disease.Methods: This is a retrospective data study of all children with IgAN. Patients who had a histopathologically proven diagnosis of IgAN and were followed up for at least 5 years were included in the study. Renal biopsy, graded as Hass classification, was performed on all patients. A total of 39 patients were included in the study.Results: The mean follow-up time (± standard deviation) was 10.4 ± 3.51 (range 5–16) years. Twenty-nine patients (74.4%) were male and ten (25.6%) were female. Nineteen (48.7%) patients presented with recurrent macroscopic hematuria, ten (25.6%) with microscopic hematuria ± proteinuria, six (15.4%) with nephritic syndrome, and four (10.3%) with nephrotic syndrome. All patients underwent a renal biopsy, which was graded according to the Hass classification. At the end of follow-up time, 18 (46.1%) patients were normal, 15 (38.5%) had minor urinary abnormalities, three (7.7%) had active renal disease, and three (7.7%) developed renal failure.Conclusion: The results of the present study are better than those from most other series. The majority of children with IgAN in this study were admitted with recurrent macroscopic hematuria and found to have a good prognosis. We suggest that children with IgAN have a good prognosis in the first 5-year follow-up period.Keywords: immunoglobulin A nephropathy, childhood, prognosishttp://www.dovepress.com/outcome-results-in-children-with-iga-nephropathy-a-single-center-exper-a9104 |
| spellingShingle | Kaplan Bulut I Mir S Sozeri B Bulut MO Sen S Dincel N Outcome results in children with IgA nephropathy: a single center experience International Journal of Nephrology and Renovascular Disease |
| title | Outcome results in children with IgA nephropathy: a single center experience |
| title_full | Outcome results in children with IgA nephropathy: a single center experience |
| title_fullStr | Outcome results in children with IgA nephropathy: a single center experience |
| title_full_unstemmed | Outcome results in children with IgA nephropathy: a single center experience |
| title_short | Outcome results in children with IgA nephropathy: a single center experience |
| title_sort | outcome results in children with iga nephropathy a single center experience |
| url | http://www.dovepress.com/outcome-results-in-children-with-iga-nephropathy-a-single-center-exper-a9104 |
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