Diabetic striatopathy: A case series of rare and treatable movement disorder
OBJECTIVE: Diabetic striatopathy (DS) is characterized by a hyperglycemic state associated with chorea/ballism, and/or striatal hyperdensity on computed tomography, or hyperintensity on T1-weighted magnetic resonance imaging. To date, there have been only a few case series reported in the literature...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Annals of Movement Disorders |
| Subjects: | |
| Online Access: | http://www.aomd.in/article.asp?issn=2590-3446;year=2023;volume=6;issue=1;spage=26;epage=29;aulast=Ranjan |
| _version_ | 1797824528241393664 |
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| author | Abhay Ranjan Sanaullah Mudassir Neetu Sinha Abhishek Kumar |
| author_facet | Abhay Ranjan Sanaullah Mudassir Neetu Sinha Abhishek Kumar |
| author_sort | Abhay Ranjan |
| collection | DOAJ |
| description | OBJECTIVE: Diabetic striatopathy (DS) is characterized by a hyperglycemic state associated with chorea/ballism, and/or striatal hyperdensity on computed tomography, or hyperintensity on T1-weighted magnetic resonance imaging. To date, there have been only a few case series reported in the literature on this topic. In the present study, we report four cases of DS associated with movement disorders. METHODS: The patients were recruited based on the presence of hyperglycemia associated with chorea/ballism or striatal hyperintensity on T1-weighted magnetic resonance imaging. RESULTS: Four patients with DS (two men and two women), with a mean age of 61 years, were included in our study. Three out of the four patients had a previous diagnosis of type 2 diabetes mellitus. The mean blood glucose level on admission and glycated hemoglobin were 390.25 mg/dl and 12.45%, respectively. Hemiballism was present in two patients: one patient had dystonia and the other had choreiform movement at presentation. The putamen was affected in all patients, with involvement of the globus pallidus and caudate nucleus in one patient. All patients had resolution of their abnormal movements after glucose-lowering therapy, with additional use of anti-chorea medication in three patients. CONCLUSION: DS should be considered in elderly patients who present with chorea/ballism/dystonia and should be accordingly managed with resolution of abnormal movements. In addition, dystonia can be a presenting symptom in DS. |
| first_indexed | 2024-03-13T10:40:19Z |
| format | Article |
| id | doaj.art-aeed0029e5f94b3ba2cf49871d1716a0 |
| institution | Directory Open Access Journal |
| issn | 2590-3446 2590-3454 |
| language | English |
| last_indexed | 2024-03-13T10:40:19Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Movement Disorders |
| spelling | doaj.art-aeed0029e5f94b3ba2cf49871d1716a02023-05-18T04:41:44ZengWolters Kluwer Medknow PublicationsAnnals of Movement Disorders2590-34462590-34542023-01-0161262910.4103/aomd.aomd_62_21Diabetic striatopathy: A case series of rare and treatable movement disorderAbhay RanjanSanaullah MudassirNeetu SinhaAbhishek KumarOBJECTIVE: Diabetic striatopathy (DS) is characterized by a hyperglycemic state associated with chorea/ballism, and/or striatal hyperdensity on computed tomography, or hyperintensity on T1-weighted magnetic resonance imaging. To date, there have been only a few case series reported in the literature on this topic. In the present study, we report four cases of DS associated with movement disorders. METHODS: The patients were recruited based on the presence of hyperglycemia associated with chorea/ballism or striatal hyperintensity on T1-weighted magnetic resonance imaging. RESULTS: Four patients with DS (two men and two women), with a mean age of 61 years, were included in our study. Three out of the four patients had a previous diagnosis of type 2 diabetes mellitus. The mean blood glucose level on admission and glycated hemoglobin were 390.25 mg/dl and 12.45%, respectively. Hemiballism was present in two patients: one patient had dystonia and the other had choreiform movement at presentation. The putamen was affected in all patients, with involvement of the globus pallidus and caudate nucleus in one patient. All patients had resolution of their abnormal movements after glucose-lowering therapy, with additional use of anti-chorea medication in three patients. CONCLUSION: DS should be considered in elderly patients who present with chorea/ballism/dystonia and should be accordingly managed with resolution of abnormal movements. In addition, dystonia can be a presenting symptom in DS.http://www.aomd.in/article.asp?issn=2590-3446;year=2023;volume=6;issue=1;spage=26;epage=29;aulast=Ranjanchorea hyperglycemia basal ganglia syndromediabetic hemiballism/hemichoreadystoniadiabetic striatopathyhyperglycemic non-ketotic hemichorea/hemiballism |
| spellingShingle | Abhay Ranjan Sanaullah Mudassir Neetu Sinha Abhishek Kumar Diabetic striatopathy: A case series of rare and treatable movement disorder Annals of Movement Disorders chorea hyperglycemia basal ganglia syndrome diabetic hemiballism/hemichorea dystonia diabetic striatopathy hyperglycemic non-ketotic hemichorea/hemiballism |
| title | Diabetic striatopathy: A case series of rare and treatable movement disorder |
| title_full | Diabetic striatopathy: A case series of rare and treatable movement disorder |
| title_fullStr | Diabetic striatopathy: A case series of rare and treatable movement disorder |
| title_full_unstemmed | Diabetic striatopathy: A case series of rare and treatable movement disorder |
| title_short | Diabetic striatopathy: A case series of rare and treatable movement disorder |
| title_sort | diabetic striatopathy a case series of rare and treatable movement disorder |
| topic | chorea hyperglycemia basal ganglia syndrome diabetic hemiballism/hemichorea dystonia diabetic striatopathy hyperglycemic non-ketotic hemichorea/hemiballism |
| url | http://www.aomd.in/article.asp?issn=2590-3446;year=2023;volume=6;issue=1;spage=26;epage=29;aulast=Ranjan |
| work_keys_str_mv | AT abhayranjan diabeticstriatopathyacaseseriesofrareandtreatablemovementdisorder AT sanaullahmudassir diabeticstriatopathyacaseseriesofrareandtreatablemovementdisorder AT neetusinha diabeticstriatopathyacaseseriesofrareandtreatablemovementdisorder AT abhishekkumar diabeticstriatopathyacaseseriesofrareandtreatablemovementdisorder |