Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review
The outbreak of the coronavirus (COVID-19) has heightened awareness of the importance of quick and easy testing. The convenience, speed, and timely results from point-of-care testing (POCT) in all vitro diagnostic devices has drawn the strong interest of researchers. However, there are still many ch...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2022-10-01
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Series: | Frontiers in Bioengineering and Biotechnology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020444/full |
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author | Ziyu He Changsheng Liu Zhongyu Li Zhou Chu Xiang Chen Xupeng Chen Yuan Guo |
author_facet | Ziyu He Changsheng Liu Zhongyu Li Zhou Chu Xiang Chen Xupeng Chen Yuan Guo |
author_sort | Ziyu He |
collection | DOAJ |
description | The outbreak of the coronavirus (COVID-19) has heightened awareness of the importance of quick and easy testing. The convenience, speed, and timely results from point-of-care testing (POCT) in all vitro diagnostic devices has drawn the strong interest of researchers. However, there are still many challenges in the development of POCT devices, such as the pretreatment of samples, detection sensitivity, specificity, and so on. It is anticipated that the unique properties of nanomaterials, e.g., their magnetic, optical, thermal, and electrically conductive features, will address the deficiencies that currently exist in POCT devices. In this review, we mainly analyze the work processes of POCT devices, especially in nucleic acid detection, and summarize how novel nanomaterials used in various aspects of POCT products can improve performance, with the ultimate aims of offering new ideas for the application of nanomaterials and the overall development of POCT devices. |
first_indexed | 2024-04-13T19:06:15Z |
format | Article |
id | doaj.art-aeedb4b8a18d4d71889edbec2033636d |
institution | Directory Open Access Journal |
issn | 2296-4185 |
language | English |
last_indexed | 2024-04-13T19:06:15Z |
publishDate | 2022-10-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Bioengineering and Biotechnology |
spelling | doaj.art-aeedb4b8a18d4d71889edbec2033636d2022-12-22T02:33:58ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-10-011010.3389/fbioe.2022.10204441020444Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A reviewZiyu He0Changsheng Liu1Zhongyu Li2Zhou Chu3Xiang Chen4Xupeng Chen5Yuan Guo6Department of Scientific Research, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, ChinaDepartment of Scientific Research, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, ChinaDepartment of Blood Transfusion, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, ChinaDepartment of Scientific Research, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, ChinaDepartment of Clinical Laboratory, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, ChinaDepartment of Scientific Research, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, ChinaDepartment of Cardiovascular Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, ChinaThe outbreak of the coronavirus (COVID-19) has heightened awareness of the importance of quick and easy testing. The convenience, speed, and timely results from point-of-care testing (POCT) in all vitro diagnostic devices has drawn the strong interest of researchers. However, there are still many challenges in the development of POCT devices, such as the pretreatment of samples, detection sensitivity, specificity, and so on. It is anticipated that the unique properties of nanomaterials, e.g., their magnetic, optical, thermal, and electrically conductive features, will address the deficiencies that currently exist in POCT devices. In this review, we mainly analyze the work processes of POCT devices, especially in nucleic acid detection, and summarize how novel nanomaterials used in various aspects of POCT products can improve performance, with the ultimate aims of offering new ideas for the application of nanomaterials and the overall development of POCT devices.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020444/fullnanomaterialnucleic acid detectionpoint-of-care testing devicessensornucleic acid enrichment |
spellingShingle | Ziyu He Changsheng Liu Zhongyu Li Zhou Chu Xiang Chen Xupeng Chen Yuan Guo Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review Frontiers in Bioengineering and Biotechnology nanomaterial nucleic acid detection point-of-care testing devices sensor nucleic acid enrichment |
title | Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review |
title_full | Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review |
title_fullStr | Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review |
title_full_unstemmed | Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review |
title_short | Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review |
title_sort | advances in the use of nanomaterials for nucleic acid detection in point of care testing devices a review |
topic | nanomaterial nucleic acid detection point-of-care testing devices sensor nucleic acid enrichment |
url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020444/full |
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