| Summary: | Abstract Background We investigated the feasibility of using a machine learning tool’s relevance predictions to expedite title and abstract screening. Methods We subjected 11 systematic reviews and six rapid reviews to four retrospective screening simulations (automated and semi-automated approaches to single-reviewer and dual independent screening) in Abstrackr, a freely-available machine learning software. We calculated the proportion missed, workload savings, and time savings compared to single-reviewer and dual independent screening by human reviewers. We performed cited reference searches to determine if missed studies would be identified via reference list scanning. Results For systematic reviews, the semi-automated, dual independent screening approach provided the best balance of time savings (median (range) 20 (3–82) hours) and reliability (median (range) proportion missed records, 1 (0–14)%). The cited references search identified 59% (n = 10/17) of the records missed. For the rapid reviews, the fully and semi-automated approaches saved time (median (range) 9 (2–18) hours and 3 (1–10) hours, respectively), but less so than for the systematic reviews. The median (range) proportion missed records for both approaches was 6 (0–22)%. Conclusion Using Abstrackr to assist one of two reviewers in systematic reviews saves time with little risk of missing relevant records. Many missed records would be identified via other means.
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