Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment
Lung cancer is managed using conventional therapies, including chemotherapy, radiation therapy, or a combination of both. Each of these therapies has its own limitations, such as the indiscriminate killing of normal as well as cancer cells, the solubility of the chemotherapeutic drugs, rapid clearan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/14/7/1370 |
| _version_ | 1797589190992461824 |
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| author | Agnishwar Girigoswami Koyeli Girigoswami |
| author_facet | Agnishwar Girigoswami Koyeli Girigoswami |
| author_sort | Agnishwar Girigoswami |
| collection | DOAJ |
| description | Lung cancer is managed using conventional therapies, including chemotherapy, radiation therapy, or a combination of both. Each of these therapies has its own limitations, such as the indiscriminate killing of normal as well as cancer cells, the solubility of the chemotherapeutic drugs, rapid clearance of the drugs from circulation before reaching the tumor site, the resistance of cancer cells to radiation, and over-sensitization of normal cells to radiation. Other treatment modalities include gene therapy, immunological checkpoint inhibitors, drug repurposing, and in situ cryo-immune engineering (ICIE) strategy. Nanotechnology has come to the rescue to overcome many shortfalls of conventional therapies. Some of the nano-formulated chemotherapeutic drugs, as well as nanoparticles and nanostructures with surface modifications, have been used for effective cancer cell killing and radio sensitization, respectively. Nano-enabled drug delivery systems act as cargo to deliver the sensitizer molecules specifically to the tumor cells, thereby enabling the radiation therapy to be more effective. In this review, we have discussed the different conventional chemotherapies and radiation therapies used for inhibiting lung cancer. We have also discussed the improvement in chemotherapy and radiation sensitization using nanoparticles. |
| first_indexed | 2024-03-11T01:02:59Z |
| format | Article |
| id | doaj.art-aef134934f1d485cbad08bfbca386b95 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T01:02:59Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-aef134934f1d485cbad08bfbca386b952023-11-18T19:29:26ZengMDPI AGGenes2073-44252023-06-01147137010.3390/genes14071370Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer TreatmentAgnishwar Girigoswami0Koyeli Girigoswami1Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam, Chennai 603103, IndiaMedical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Kelambakkam, Chennai 603103, IndiaLung cancer is managed using conventional therapies, including chemotherapy, radiation therapy, or a combination of both. Each of these therapies has its own limitations, such as the indiscriminate killing of normal as well as cancer cells, the solubility of the chemotherapeutic drugs, rapid clearance of the drugs from circulation before reaching the tumor site, the resistance of cancer cells to radiation, and over-sensitization of normal cells to radiation. Other treatment modalities include gene therapy, immunological checkpoint inhibitors, drug repurposing, and in situ cryo-immune engineering (ICIE) strategy. Nanotechnology has come to the rescue to overcome many shortfalls of conventional therapies. Some of the nano-formulated chemotherapeutic drugs, as well as nanoparticles and nanostructures with surface modifications, have been used for effective cancer cell killing and radio sensitization, respectively. Nano-enabled drug delivery systems act as cargo to deliver the sensitizer molecules specifically to the tumor cells, thereby enabling the radiation therapy to be more effective. In this review, we have discussed the different conventional chemotherapies and radiation therapies used for inhibiting lung cancer. We have also discussed the improvement in chemotherapy and radiation sensitization using nanoparticles.https://www.mdpi.com/2073-4425/14/7/1370lung cancerchemotherapyradiation therapynano sensitizersradiation protection by nanoparticles |
| spellingShingle | Agnishwar Girigoswami Koyeli Girigoswami Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment Genes lung cancer chemotherapy radiation therapy nano sensitizers radiation protection by nanoparticles |
| title | Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment |
| title_full | Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment |
| title_fullStr | Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment |
| title_full_unstemmed | Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment |
| title_short | Potential Applications of Nanoparticles in Improving the Outcome of Lung Cancer Treatment |
| title_sort | potential applications of nanoparticles in improving the outcome of lung cancer treatment |
| topic | lung cancer chemotherapy radiation therapy nano sensitizers radiation protection by nanoparticles |
| url | https://www.mdpi.com/2073-4425/14/7/1370 |
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