Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi
The search for new classes of fungicides has long been important in plant protection due to the development of fungal resistance to currently used agrochemicals. Organic peroxides have long been regarded as exotic and unstable compounds. The discovery of the antimalarial activity of the peroxide nat...
| Main Authors: | , , , , , , , , |
|---|---|
| 格式: | Article |
| 語言: | English |
| 出版: |
MDPI AG
2023-06-01
|
| 叢編: | Agrochemicals |
| 主題: | |
| 在線閱讀: | https://www.mdpi.com/2813-3145/2/3/21 |
| _version_ | 1827727678343479296 |
|---|---|
| author | Ivan A. Yaremenko Peter S. Radulov Yulia Yu. Belyakova Dmitrii I. Fomenkov Vera A. Vil’ Maria A. Kuznetsova Valentina N. Demidova Alexei P. Glinushkin Alexander O. Terent’ev |
| author_facet | Ivan A. Yaremenko Peter S. Radulov Yulia Yu. Belyakova Dmitrii I. Fomenkov Vera A. Vil’ Maria A. Kuznetsova Valentina N. Demidova Alexei P. Glinushkin Alexander O. Terent’ev |
| author_sort | Ivan A. Yaremenko |
| collection | DOAJ |
| description | The search for new classes of fungicides has long been important in plant protection due to the development of fungal resistance to currently used agrochemicals. Organic peroxides have long been regarded as exotic and unstable compounds. The discovery of the antimalarial activity of the peroxide natural product Artemisinin, an achievement that was recently recognized with the Nobel Prize, has brought organic peroxides into the medicinal and agrochemistry. In this paper, fungicidal activity of synthesized organic peroxides—geminal bishydroperoxide, bridged 1,2,4,5-tetraoxanes, and tricyclic monoperoxides—were tested in vitro against an important species of phytopathogenic fungi (<i>F. culmorum</i>, <i>R. solani</i>, <i>A. solani</i>, <i>P. infestans</i>, <i>C. coccodes</i>). We discovered that substituted bridged 1,2,4,5-tetraoxanes exhibit fungicidal activity comparable or superior to azoxystrobin and superior to geminal bishydroperoxide and tricyclic monoperoxides. The contact mode of action was demonstrated for the bridged 1,2,4,5-tetraoxane. |
| first_indexed | 2024-03-10T23:08:47Z |
| format | Article |
| id | doaj.art-aef1a6d97ff040b0b0b51d2d7daca39d |
| institution | Directory Open Access Journal |
| issn | 2813-3145 |
| language | English |
| last_indexed | 2024-03-10T23:08:47Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Agrochemicals |
| spelling | doaj.art-aef1a6d97ff040b0b0b51d2d7daca39d2023-11-19T09:08:43ZengMDPI AGAgrochemicals2813-31452023-06-012335536610.3390/agrochemicals2030021Cyclic Organic Peroxides as New Fungicides against Phytopathogenic FungiIvan A. Yaremenko0Peter S. Radulov1Yulia Yu. Belyakova2Dmitrii I. Fomenkov3Vera A. Vil’4Maria A. Kuznetsova5Valentina N. Demidova6Alexei P. Glinushkin7Alexander O. Terent’ev8N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaN. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaN. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaN. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaN. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaAll-Russian Research Institute for Phytopathology, B. Vyazyomy, 143050 Moscow, RussiaAll-Russian Research Institute for Phytopathology, B. Vyazyomy, 143050 Moscow, RussiaAll-Russian Research Institute for Phytopathology, B. Vyazyomy, 143050 Moscow, RussiaN. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospekt, 119991 Moscow, RussiaThe search for new classes of fungicides has long been important in plant protection due to the development of fungal resistance to currently used agrochemicals. Organic peroxides have long been regarded as exotic and unstable compounds. The discovery of the antimalarial activity of the peroxide natural product Artemisinin, an achievement that was recently recognized with the Nobel Prize, has brought organic peroxides into the medicinal and agrochemistry. In this paper, fungicidal activity of synthesized organic peroxides—geminal bishydroperoxide, bridged 1,2,4,5-tetraoxanes, and tricyclic monoperoxides—were tested in vitro against an important species of phytopathogenic fungi (<i>F. culmorum</i>, <i>R. solani</i>, <i>A. solani</i>, <i>P. infestans</i>, <i>C. coccodes</i>). We discovered that substituted bridged 1,2,4,5-tetraoxanes exhibit fungicidal activity comparable or superior to azoxystrobin and superior to geminal bishydroperoxide and tricyclic monoperoxides. The contact mode of action was demonstrated for the bridged 1,2,4,5-tetraoxane.https://www.mdpi.com/2813-3145/2/3/21crop protectionfungicidesorganic peroxides |
| spellingShingle | Ivan A. Yaremenko Peter S. Radulov Yulia Yu. Belyakova Dmitrii I. Fomenkov Vera A. Vil’ Maria A. Kuznetsova Valentina N. Demidova Alexei P. Glinushkin Alexander O. Terent’ev Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi Agrochemicals crop protection fungicides organic peroxides |
| title | Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi |
| title_full | Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi |
| title_fullStr | Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi |
| title_full_unstemmed | Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi |
| title_short | Cyclic Organic Peroxides as New Fungicides against Phytopathogenic Fungi |
| title_sort | cyclic organic peroxides as new fungicides against phytopathogenic fungi |
| topic | crop protection fungicides organic peroxides |
| url | https://www.mdpi.com/2813-3145/2/3/21 |
| work_keys_str_mv | AT ivanayaremenko cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT petersradulov cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT yuliayubelyakova cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT dmitriiifomenkov cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT veraavil cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT mariaakuznetsova cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT valentinandemidova cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT alexeipglinushkin cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi AT alexanderoterentev cyclicorganicperoxidesasnewfungicidesagainstphytopathogenicfungi |