Application of genome-wide single nucleotide polymorphism typing: simple association and beyond.
The International HapMap Project and the arrival of technologies that type more than 100,000 SNPs in a single experiment have made genome-wide single nucleotide polymorphism (GW-SNP) assay a realistic endeavor. This has sparked considerable debate regarding the promise of GW-SNP typing to identify g...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2006-10-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC1592240?pdf=render |
| _version_ | 1830482369422819328 |
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| author | J Raphael Gibbs Andrew Singleton |
| author_facet | J Raphael Gibbs Andrew Singleton |
| author_sort | J Raphael Gibbs |
| collection | DOAJ |
| description | The International HapMap Project and the arrival of technologies that type more than 100,000 SNPs in a single experiment have made genome-wide single nucleotide polymorphism (GW-SNP) assay a realistic endeavor. This has sparked considerable debate regarding the promise of GW-SNP typing to identify genetic association in disease. As has already been shown, this approach has the potential to localize common genetic variation underlying disease risk. The data provided from this technology also lends itself to several other lines of investigation; autozygosity mapping in consanguineous families and outbred populations, direct detection of structural variation, admixture analysis, and other population genetic approaches. In this review we will discuss the potential uses and practical application of GW-SNP typing including those above and beyond simple association testing. |
| first_indexed | 2024-12-21T17:32:43Z |
| format | Article |
| id | doaj.art-aef1e880924f4e76bdcc00b39279264e |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-21T17:32:43Z |
| publishDate | 2006-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-aef1e880924f4e76bdcc00b39279264e2022-12-21T18:55:52ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042006-10-01210e15010.1371/journal.pgen.0020150Application of genome-wide single nucleotide polymorphism typing: simple association and beyond.J Raphael GibbsAndrew SingletonThe International HapMap Project and the arrival of technologies that type more than 100,000 SNPs in a single experiment have made genome-wide single nucleotide polymorphism (GW-SNP) assay a realistic endeavor. This has sparked considerable debate regarding the promise of GW-SNP typing to identify genetic association in disease. As has already been shown, this approach has the potential to localize common genetic variation underlying disease risk. The data provided from this technology also lends itself to several other lines of investigation; autozygosity mapping in consanguineous families and outbred populations, direct detection of structural variation, admixture analysis, and other population genetic approaches. In this review we will discuss the potential uses and practical application of GW-SNP typing including those above and beyond simple association testing.http://europepmc.org/articles/PMC1592240?pdf=render |
| spellingShingle | J Raphael Gibbs Andrew Singleton Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. PLoS Genetics |
| title | Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. |
| title_full | Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. |
| title_fullStr | Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. |
| title_full_unstemmed | Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. |
| title_short | Application of genome-wide single nucleotide polymorphism typing: simple association and beyond. |
| title_sort | application of genome wide single nucleotide polymorphism typing simple association and beyond |
| url | http://europepmc.org/articles/PMC1592240?pdf=render |
| work_keys_str_mv | AT jraphaelgibbs applicationofgenomewidesinglenucleotidepolymorphismtypingsimpleassociationandbeyond AT andrewsingleton applicationofgenomewidesinglenucleotidepolymorphismtypingsimpleassociationandbeyond |