HMG-CoA Reductase Inhibitor, Simvastatin Is Effective in Decreasing Degree of Myocarditis by Inhibiting Metalloproteinases Activation

HMG-CoA Reductase Inhibitor, Simvastatin Is Effective in Decreasing Degree of Myocarditis by Inhibiting Metalloproteinases Activation

Background: Acute myocarditis often progresses to heart failure because there is no effective, etiology-targeted therapy of this disease. Simvastatin has been shown to be cardioprotective by decreasing matrix metalloproteinases’ (MMPs) activity. The study was designed to determine whether simvastati...

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Bibliographic Details
Main Authors: Monika Skrzypiec-Spring, Agnieszka Sapa-Wojciechowska, Katarzyna Haczkiewicz-Leśniak, Tomasz Piasecki, Joanna Kwiatkowska, Marzenna Podhorska-Okołów, Adam Szeląg
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Biomolecules
Subjects:
experimental autoimmune myocarditis
metalloproteinases
simvastatin
Online Access:https://www.mdpi.com/2218-273X/11/10/1415

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