Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease
Aim: Whether the total coronary atherosclerotic plaque burden is independently associated with myocardial ischemia in non-obstructive coronary artery disease (CAD) is not well established. We aimed to test the association of total plaque burden quantified by coronary computed tomography angiography...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906721001196 |
| _version_ | 1818778936318885888 |
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| author | Ingeborg Eskerud Eva Gerdts Terje H. Larsen Judit Simon Pál Maurovich-Horvat Mai Tone Lønnebakken |
| author_facet | Ingeborg Eskerud Eva Gerdts Terje H. Larsen Judit Simon Pál Maurovich-Horvat Mai Tone Lønnebakken |
| author_sort | Ingeborg Eskerud |
| collection | DOAJ |
| description | Aim: Whether the total coronary atherosclerotic plaque burden is independently associated with myocardial ischemia in non-obstructive coronary artery disease (CAD) is not well established. We aimed to test the association of total plaque burden quantified by coronary computed tomography angiography (CCTA) with myocardial ischemia in patients with chronic coronary syndrome and non-obstructive CAD. Methods: We included 125 patients (age 62 ± 9 years, 58% women) with chronic coronary syndrome and non-obstructive CAD (stenosis < 50%) by CCTA, who were grouped according to presence or absence of myocardial ischemia by myocardial contrast stress echocardiography. Total plaque burden was quantified by CCTA as the total plaque volume in the main coronary arteries, and positive remodelling was defined as remodelling index > 1.10. Results: Patients with myocardial ischemia (n = 66) had higher total plaque burden (847 ± 245 mm3 vs. 758 ± 251 mm3, p = 0.049) and higher left ventricular (LV) mass index (42.1 ± 9.9 g/m2.7 vs. 37.3 ± 8.0 g/m2.7, p = 0.004), while age, sex, prevalence of hypertension, diabetes, calcium score and positive remodelling did not differ between the groups (all p > 0.05). In multivariable regression analysis, total plaque burden remained associated with presence of myocardial ischemia (OR 1.02, 95% CI 1.00–1.04, p = 0.045) independent of age, sex, hypertension, diabetes, LV mass index, coronary calcium score and positive remodelling. Conclusion: Total coronary artery plaque burden by CCTA was independently associated with myocardial ischemia in patients with non-obstructive CAD. Whether plaque quantification is useful for clinical management of patients with non-obstructive CAD should be tested in prospective studies.ClinicalTrials.gov: Identifier NCT01853527. |
| first_indexed | 2024-12-18T11:52:38Z |
| format | Article |
| id | doaj.art-aef38c41f7c64ea498436b3ea3bd1623 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-18T11:52:38Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-aef38c41f7c64ea498436b3ea3bd16232022-12-21T21:09:08ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672021-08-0135100831Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery diseaseIngeborg Eskerud0Eva Gerdts1Terje H. Larsen2Judit Simon3Pál Maurovich-Horvat4Mai Tone Lønnebakken5Department of Clinical Science, University of Bergen, PO box 7804, N-5020 Bergen, Norway; Corresponding author at: Department of Clinical Science, University of Bergen, Postbox 7804, N-5020 Bergen, Norway.Department of Clinical Science, University of Bergen, PO box 7804, N-5020 Bergen, NorwayDepartment of Heart Disease, Haukeland University Hospital, PO box 1400, N-5021 Bergen, Norway; Department of Biomedicine, University of Bergen, Postbox 7804, N-5020 Bergen, NorwayMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, HungaryMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68 Városmajor Street, Budapest, Hungary; Medical Imaging Centre, Semmelweis University, 18 Hataror ut, 1122, Budapest, HungaryDepartment of Clinical Science, University of Bergen, PO box 7804, N-5020 Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, PO box 1400, N-5021 Bergen, NorwayAim: Whether the total coronary atherosclerotic plaque burden is independently associated with myocardial ischemia in non-obstructive coronary artery disease (CAD) is not well established. We aimed to test the association of total plaque burden quantified by coronary computed tomography angiography (CCTA) with myocardial ischemia in patients with chronic coronary syndrome and non-obstructive CAD. Methods: We included 125 patients (age 62 ± 9 years, 58% women) with chronic coronary syndrome and non-obstructive CAD (stenosis < 50%) by CCTA, who were grouped according to presence or absence of myocardial ischemia by myocardial contrast stress echocardiography. Total plaque burden was quantified by CCTA as the total plaque volume in the main coronary arteries, and positive remodelling was defined as remodelling index > 1.10. Results: Patients with myocardial ischemia (n = 66) had higher total plaque burden (847 ± 245 mm3 vs. 758 ± 251 mm3, p = 0.049) and higher left ventricular (LV) mass index (42.1 ± 9.9 g/m2.7 vs. 37.3 ± 8.0 g/m2.7, p = 0.004), while age, sex, prevalence of hypertension, diabetes, calcium score and positive remodelling did not differ between the groups (all p > 0.05). In multivariable regression analysis, total plaque burden remained associated with presence of myocardial ischemia (OR 1.02, 95% CI 1.00–1.04, p = 0.045) independent of age, sex, hypertension, diabetes, LV mass index, coronary calcium score and positive remodelling. Conclusion: Total coronary artery plaque burden by CCTA was independently associated with myocardial ischemia in patients with non-obstructive CAD. Whether plaque quantification is useful for clinical management of patients with non-obstructive CAD should be tested in prospective studies.ClinicalTrials.gov: Identifier NCT01853527.http://www.sciencedirect.com/science/article/pii/S2352906721001196Non-obstructive coronary artery diseaseINOCAMyocardial ischemiaCoronary computed tomography angiographyCoronary plaque burdenCoronary plaque volume |
| spellingShingle | Ingeborg Eskerud Eva Gerdts Terje H. Larsen Judit Simon Pál Maurovich-Horvat Mai Tone Lønnebakken Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease International Journal of Cardiology: Heart & Vasculature Non-obstructive coronary artery disease INOCA Myocardial ischemia Coronary computed tomography angiography Coronary plaque burden Coronary plaque volume |
| title | Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease |
| title_full | Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease |
| title_fullStr | Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease |
| title_full_unstemmed | Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease |
| title_short | Total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non-obstructive coronary artery disease |
| title_sort | total coronary atherosclerotic plaque burden is associated with myocardial ischemia in non obstructive coronary artery disease |
| topic | Non-obstructive coronary artery disease INOCA Myocardial ischemia Coronary computed tomography angiography Coronary plaque burden Coronary plaque volume |
| url | http://www.sciencedirect.com/science/article/pii/S2352906721001196 |
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