Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis
Osteoporosis (OP), osteoarthritis (OA), and rheumatoid arthritis (RA) are common bone and joint diseases with a high incidence and long duration. Thus, these conditions can affect the lives of middle-aged and elderly people. Tea drinking is a traditional lifestyle in China, and the long-term intake...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1289777/full |
| _version_ | 1797311667785170944 |
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| author | Xinyu Xie Xinyu Xie Jiehui Fu Weiying Gou Weiying Gou Yifei Qin Yifei Qin Dingzhen Wang Dingzhen Wang Zuer Huang Zuer Huang Lili Wang Lili Wang Xihai Li Xihai Li |
| author_facet | Xinyu Xie Xinyu Xie Jiehui Fu Weiying Gou Weiying Gou Yifei Qin Yifei Qin Dingzhen Wang Dingzhen Wang Zuer Huang Zuer Huang Lili Wang Lili Wang Xihai Li Xihai Li |
| author_sort | Xinyu Xie |
| collection | DOAJ |
| description | Osteoporosis (OP), osteoarthritis (OA), and rheumatoid arthritis (RA) are common bone and joint diseases with a high incidence and long duration. Thus, these conditions can affect the lives of middle-aged and elderly people. Tea drinking is a traditional lifestyle in China, and the long-term intake of tea and its active ingredients is beneficial to human health. However, the mechanisms of action of tea and its active ingredients against OP, OA, and RA are not completely elucidated. This study aimed to assess the therapeutic role and related mechanisms of tea and its active ingredients in OP, OA, and RA. Moreover, it expanded the potential mechanisms of tea efficacy based on network pharmacology and molecular docking. Results showed that tea has potential anti-COX properties and hormone-like effects. Compared with a single component, different tea components synergize or antagonize each other, thereby resulting in a more evident dual effect. In conclusion, tea has great potential in the medical and healthcare fields. Nevertheless, further research on the composition, proportion, and synergistic mechanism of several tea components should be performed. |
| first_indexed | 2024-03-08T02:03:02Z |
| format | Article |
| id | doaj.art-aef48de493c6467db3a1397256ff3423 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-08T02:03:02Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-aef48de493c6467db3a1397256ff34232024-02-14T04:48:42ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-02-011110.3389/fmed.2024.12897771289777Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritisXinyu Xie0Xinyu Xie1Jiehui Fu2Weiying Gou3Weiying Gou4Yifei Qin5Yifei Qin6Dingzhen Wang7Dingzhen Wang8Zuer Huang9Zuer Huang10Lili Wang11Lili Wang12Xihai Li13Xihai Li14Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaDepartment of Sports Medicine (Orthopedics), Fujian University of Traditional Chinese Medicine Subsidiary Rehabilitation Hospital, Fuzhou, ChinaAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaAcademy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaFujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, ChinaOsteoporosis (OP), osteoarthritis (OA), and rheumatoid arthritis (RA) are common bone and joint diseases with a high incidence and long duration. Thus, these conditions can affect the lives of middle-aged and elderly people. Tea drinking is a traditional lifestyle in China, and the long-term intake of tea and its active ingredients is beneficial to human health. However, the mechanisms of action of tea and its active ingredients against OP, OA, and RA are not completely elucidated. This study aimed to assess the therapeutic role and related mechanisms of tea and its active ingredients in OP, OA, and RA. Moreover, it expanded the potential mechanisms of tea efficacy based on network pharmacology and molecular docking. Results showed that tea has potential anti-COX properties and hormone-like effects. Compared with a single component, different tea components synergize or antagonize each other, thereby resulting in a more evident dual effect. In conclusion, tea has great potential in the medical and healthcare fields. Nevertheless, further research on the composition, proportion, and synergistic mechanism of several tea components should be performed.https://www.frontiersin.org/articles/10.3389/fmed.2024.1289777/fullCamellia sinensisosteoporosisosteoarthritisrheumatoid arthritiscyberpharmacologymolecular docking |
| spellingShingle | Xinyu Xie Xinyu Xie Jiehui Fu Weiying Gou Weiying Gou Yifei Qin Yifei Qin Dingzhen Wang Dingzhen Wang Zuer Huang Zuer Huang Lili Wang Lili Wang Xihai Li Xihai Li Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis Frontiers in Medicine Camellia sinensis osteoporosis osteoarthritis rheumatoid arthritis cyberpharmacology molecular docking |
| title | Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis |
| title_full | Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis |
| title_fullStr | Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis |
| title_full_unstemmed | Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis |
| title_short | Potential mechanism of tea for treating osteoporosis, osteoarthritis, and rheumatoid arthritis |
| title_sort | potential mechanism of tea for treating osteoporosis osteoarthritis and rheumatoid arthritis |
| topic | Camellia sinensis osteoporosis osteoarthritis rheumatoid arthritis cyberpharmacology molecular docking |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1289777/full |
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