STAT3 is required for Smo‐dependent signaling and mediates Smo‐targeted treatment resistance and tumorigenesis in Shh medulloblastoma

STAT3 is required for Smo‐dependent signaling and mediates Smo‐targeted treatment resistance and tumorigenesis in Shh medulloblastoma

Sonic hedgehog (Shh)‐driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance. The purpose of this study was to address the critical role of signal transducer and activator of transcription 3 (STAT...

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Bibliographic Details
Main Authors: Liangping Yuan, Hongying Zhang, Jingbo Liu, Anshu Malhotra, Abhinav Dey, Bing Yu, Kishore Kumar Jella, Leon F. McSwain, Matthew J. Schniederjan, Tobey J. MacDonald
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Molecular Oncology
Subjects:
drug resistance
medulloblastoma
sonic hedgehog
STAT3
tumorigenesis
Online Access:https://doi.org/10.1002/1878-0261.13097

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