Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial Cancer
It is relevant to find new prognostic and diagnostic biomarkers for endometrial cancer. The study group consisted of 94 cases of endometrial cancer, the control group of 65 cases of normal endometrium. We evaluated PON1 and PTX3 serum levels. The ROC curve was plotted. The area under the curve was c...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/10/2024 |
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| author | Mateusz Kozłowski Kaja Michalczyk Grzegorz Witczak Sebastian Kwiatkowski Aneta Mirecka Katarzyna Nowak Ewa Pius-Sadowska Bogusław Machaliński Aneta Cymbaluk-Płoska |
| author_facet | Mateusz Kozłowski Kaja Michalczyk Grzegorz Witczak Sebastian Kwiatkowski Aneta Mirecka Katarzyna Nowak Ewa Pius-Sadowska Bogusław Machaliński Aneta Cymbaluk-Płoska |
| author_sort | Mateusz Kozłowski |
| collection | DOAJ |
| description | It is relevant to find new prognostic and diagnostic biomarkers for endometrial cancer. The study group consisted of 94 cases of endometrial cancer, the control group of 65 cases of normal endometrium. We evaluated PON1 and PTX3 serum levels. The ROC curve was plotted. The area under the curve was calculated to characterize the sensitivity and specificity of the studied parameters. Univariate and multivariate analyses were performed simultaneously using the Cox regression model. The Kaplan–Meier curve was used to assess survival. The cut-off level of PON1 was 142.6 ng/mL, with a sensitivity and specificity of 79 and 84% (<i>p</i> = 0.0321). The cut-off level of PTX3 was 4.2 ng/mL, with a sensitivity and specificity of 63 and 57% (<i>p</i> = 0.028). The favorable prognostic factor determined in serum was PON1 (for PFS: HR 0.93, 95% CI 0.86–1.03, <i>p</i> = 0.046; for OS: HR 0.96, 95% CI 0.89–1.08, <i>p</i> = 0.009). PON1 may be considered a potential biomarker in the diagnosis of endometrial cancer. Considering multivariate analysis, the PON1 serum level above the median is an independent favourable prognostic factor affecting PFS and OS. Considering Kaplan–Meier curves, longer recurrence-free survival and overall survival were found in patients with PON1 levels below the median. In view of the inconclusive results, we suggest that further studies should be conducted. |
| first_indexed | 2024-03-09T20:48:50Z |
| format | Article |
| id | doaj.art-aef60c9bfa8f4c92b8f7a0f17fe00aec |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:48:50Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-aef60c9bfa8f4c92b8f7a0f17fe00aec2023-11-23T22:39:32ZengMDPI AGAntioxidants2076-39212022-10-011110202410.3390/antiox11102024Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial CancerMateusz Kozłowski0Kaja Michalczyk1Grzegorz Witczak2Sebastian Kwiatkowski3Aneta Mirecka4Katarzyna Nowak5Ewa Pius-Sadowska6Bogusław Machaliński7Aneta Cymbaluk-Płoska8Department of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of General Pathology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecological Surgery and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandIt is relevant to find new prognostic and diagnostic biomarkers for endometrial cancer. The study group consisted of 94 cases of endometrial cancer, the control group of 65 cases of normal endometrium. We evaluated PON1 and PTX3 serum levels. The ROC curve was plotted. The area under the curve was calculated to characterize the sensitivity and specificity of the studied parameters. Univariate and multivariate analyses were performed simultaneously using the Cox regression model. The Kaplan–Meier curve was used to assess survival. The cut-off level of PON1 was 142.6 ng/mL, with a sensitivity and specificity of 79 and 84% (<i>p</i> = 0.0321). The cut-off level of PTX3 was 4.2 ng/mL, with a sensitivity and specificity of 63 and 57% (<i>p</i> = 0.028). The favorable prognostic factor determined in serum was PON1 (for PFS: HR 0.93, 95% CI 0.86–1.03, <i>p</i> = 0.046; for OS: HR 0.96, 95% CI 0.89–1.08, <i>p</i> = 0.009). PON1 may be considered a potential biomarker in the diagnosis of endometrial cancer. Considering multivariate analysis, the PON1 serum level above the median is an independent favourable prognostic factor affecting PFS and OS. Considering Kaplan–Meier curves, longer recurrence-free survival and overall survival were found in patients with PON1 levels below the median. In view of the inconclusive results, we suggest that further studies should be conducted.https://www.mdpi.com/2076-3921/11/10/2024paraoxonase-1pentraxin-3PON1PTX3diagnostic markerprognostic factor |
| spellingShingle | Mateusz Kozłowski Kaja Michalczyk Grzegorz Witczak Sebastian Kwiatkowski Aneta Mirecka Katarzyna Nowak Ewa Pius-Sadowska Bogusław Machaliński Aneta Cymbaluk-Płoska Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial Cancer Antioxidants paraoxonase-1 pentraxin-3 PON1 PTX3 diagnostic marker prognostic factor |
| title | Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial Cancer |
| title_full | Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial Cancer |
| title_fullStr | Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial Cancer |
| title_full_unstemmed | Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial Cancer |
| title_short | Evaluation of Paraoxonase-1 and Pentraxin-3 in the Diagnosis and Prognosis of Endometrial Cancer |
| title_sort | evaluation of paraoxonase 1 and pentraxin 3 in the diagnosis and prognosis of endometrial cancer |
| topic | paraoxonase-1 pentraxin-3 PON1 PTX3 diagnostic marker prognostic factor |
| url | https://www.mdpi.com/2076-3921/11/10/2024 |
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