Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy
The urinary levels of mlcroalbumin and P2-mlcroglobulin were determined in 71 patients aged 1 to 14 years with vesicoureteral reflux. According to the degree of reflux nephropathy as evidenced by dimercaptosuccinic acid (DMSA) scintigraphy, the patients were divided into 3 groups: 9 patients without...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2016-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/239 |
| Summary: | The urinary levels of mlcroalbumin and P2-mlcroglobulin were determined in 71 patients aged 1 to 14 years with vesicoureteral reflux. According to the degree of reflux nephropathy as evidenced by dimercaptosuccinic acid (DMSA) scintigraphy, the patients were divided into 3 groups: 9 patients without reflux nephropathy (Group 2); 41 with mild reflux nephropathy (Group 3); and 21 with severe reflux nephropathy (Group 4). A control group (Group 1) consisted of 29 healthy children without a history of kidney disease. Mi-croalbumin and P2-microglobulin from the morning urine portions were determined by enzyme-linked immunosorbent assay (ELISA) and recalculated with reference to urinary creatinine. A relationship was found between the urinary levels of proteins and the severity of reflux nephropathy. There was a significant rise in urinary microalbumin and P2-microglobulin excretion levels in severe reflux nephropathy. This permits the use of this study in patients with reflux nephropathy as a diagnostic marker of its severity. |
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| ISSN: | 1027-4065 2500-2228 |