Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy
The urinary levels of mlcroalbumin and P2-mlcroglobulin were determined in 71 patients aged 1 to 14 years with vesicoureteral reflux. According to the degree of reflux nephropathy as evidenced by dimercaptosuccinic acid (DMSA) scintigraphy, the patients were divided into 3 groups: 9 patients without...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2016-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
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| Online Access: | https://www.ped-perinatology.ru/jour/article/view/239 |
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| author | N. M. Zaicova V. V. Dlin L. A. Sinitsyna V. S. Gudumac A. A. Korsunsky Sh. G. Gackan |
| author_facet | N. M. Zaicova V. V. Dlin L. A. Sinitsyna V. S. Gudumac A. A. Korsunsky Sh. G. Gackan |
| author_sort | N. M. Zaicova |
| collection | DOAJ |
| description | The urinary levels of mlcroalbumin and P2-mlcroglobulin were determined in 71 patients aged 1 to 14 years with vesicoureteral reflux. According to the degree of reflux nephropathy as evidenced by dimercaptosuccinic acid (DMSA) scintigraphy, the patients were divided into 3 groups: 9 patients without reflux nephropathy (Group 2); 41 with mild reflux nephropathy (Group 3); and 21 with severe reflux nephropathy (Group 4). A control group (Group 1) consisted of 29 healthy children without a history of kidney disease. Mi-croalbumin and P2-microglobulin from the morning urine portions were determined by enzyme-linked immunosorbent assay (ELISA) and recalculated with reference to urinary creatinine. A relationship was found between the urinary levels of proteins and the severity of reflux nephropathy. There was a significant rise in urinary microalbumin and P2-microglobulin excretion levels in severe reflux nephropathy. This permits the use of this study in patients with reflux nephropathy as a diagnostic marker of its severity. |
| first_indexed | 2024-04-10T01:44:48Z |
| format | Article |
| id | doaj.art-aefb3365844a4ab89c55a6a1538930dd |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:44:48Z |
| publishDate | 2016-03-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-aefb3365844a4ab89c55a6a1538930dd2023-03-13T09:12:41ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282016-03-015956976232Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathyN. M. Zaicova0V. V. Dlin1L. A. Sinitsyna2V. S. Gudumac3A. A. Korsunsky4Sh. G. Gackan5Институт матери и ребенка, Кишинев, МолдоваНаучно-исследовательский клинический институт педиатрии, МоскваИнститут матери и ребенка, Кишинев, МолдоваИнститут матери и ребенка, Кишинев, МолдоваПервый Московский государственный медицинский университет им. И.М. Сеченова, МоскваИнститут матери и ребенка, Кишинев, МолдоваThe urinary levels of mlcroalbumin and P2-mlcroglobulin were determined in 71 patients aged 1 to 14 years with vesicoureteral reflux. According to the degree of reflux nephropathy as evidenced by dimercaptosuccinic acid (DMSA) scintigraphy, the patients were divided into 3 groups: 9 patients without reflux nephropathy (Group 2); 41 with mild reflux nephropathy (Group 3); and 21 with severe reflux nephropathy (Group 4). A control group (Group 1) consisted of 29 healthy children without a history of kidney disease. Mi-croalbumin and P2-microglobulin from the morning urine portions were determined by enzyme-linked immunosorbent assay (ELISA) and recalculated with reference to urinary creatinine. A relationship was found between the urinary levels of proteins and the severity of reflux nephropathy. There was a significant rise in urinary microalbumin and P2-microglobulin excretion levels in severe reflux nephropathy. This permits the use of this study in patients with reflux nephropathy as a diagnostic marker of its severity.https://www.ped-perinatology.ru/jour/article/view/239детипузырно-мочеточниковый рефлюксрефлюкс-нефропатия/32-микроглобулинуриямикроальбуминуриядиагностика. |
| spellingShingle | N. M. Zaicova V. V. Dlin L. A. Sinitsyna V. S. Gudumac A. A. Korsunsky Sh. G. Gackan Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy Rossijskij Vestnik Perinatologii i Pediatrii дети пузырно-мочеточниковый рефлюкс рефлюкс-нефропатия /32-микроглобулинурия микроальбуминурия диагностика. |
| title | Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy |
| title_full | Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy |
| title_fullStr | Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy |
| title_full_unstemmed | Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy |
| title_short | Microalbuminuria and P2-microglobulinuria in children with vesicoureteral reflux and reflux nephropathy |
| title_sort | microalbuminuria and p2 microglobulinuria in children with vesicoureteral reflux and reflux nephropathy |
| topic | дети пузырно-мочеточниковый рефлюкс рефлюкс-нефропатия /32-микроглобулинурия микроальбуминурия диагностика. |
| url | https://www.ped-perinatology.ru/jour/article/view/239 |
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