Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices
Daptomycin is a cyclic lipopeptide antibiotic with bactericidal effects against multidrug-resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). For critically ill patients, especially in the presence of im...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/5/904 |
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| author | Stefanie Calov Frederik Munzel Anka C. Roehr Otto Frey Lina Maria Serna Higuita Petra Wied Peter Rosenberger Helene A. Haeberle Kristian-Christos Ngamsri |
| author_facet | Stefanie Calov Frederik Munzel Anka C. Roehr Otto Frey Lina Maria Serna Higuita Petra Wied Peter Rosenberger Helene A. Haeberle Kristian-Christos Ngamsri |
| author_sort | Stefanie Calov |
| collection | DOAJ |
| description | Daptomycin is a cyclic lipopeptide antibiotic with bactericidal effects against multidrug-resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). For critically ill patients, especially in the presence of implants, daptomycin is an important therapeutic option. Left ventricle assist devices (LVADs) can be utilized for intensive care patients with end-stage heart failure as a bridge to transplant. We conducted a single-center prospective trial with critically ill adults with LVAD who received prophylactic anti-infective therapy with daptomycin. Our study aimed to evaluate the pharmacokinetics of daptomycin in the blood serum and wound fluids after LVAD implantation. Daptomycin concentration were assessed over three days using high-performance liquid chromatography (HPLC). We detected a high correlation between blood serum and wound fluid daptomycin concentration at 12 h (IC95%: 0.64 to 0.95; r = 0.86; <i>p</i> < 0.001) and 24 h (IC95%: −0.38 to 0.92; r = 0.76; <i>p</i> < 0.001) after antibiotic administration. Our pilot clinical study provides new insights into the pharmacokinetics of daptomycin from the blood into wound fluids of critically ill patients with LVADs. |
| first_indexed | 2024-03-11T03:59:51Z |
| format | Article |
| id | doaj.art-aefc0925712f4bd0bf644bb9a064331b |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T03:59:51Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-aefc0925712f4bd0bf644bb9a064331b2023-11-18T00:13:02ZengMDPI AGAntibiotics2079-63822023-05-0112590410.3390/antibiotics12050904Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist DevicesStefanie Calov0Frederik Munzel1Anka C. Roehr2Otto Frey3Lina Maria Serna Higuita4Petra Wied5Peter Rosenberger6Helene A. Haeberle7Kristian-Christos Ngamsri8Department of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University of Tübingen, 72076 Tübingen, GermanyDepartment of Anesthesiology and Intensive Care Medicine, BG Trauma Center, 72076 Tübingen, GermanyDepartment of Pharmacy, General Hospital of Heidenheim, 89522 Heidenheim, GermanyDepartment of Pharmacy, General Hospital of Heidenheim, 89522 Heidenheim, GermanyDepartment for Translational Bioinformatics and Medical Data Integration Center, Eberhard Karls University of Tübingen, 72076 Tübingen, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University of Tübingen, 72076 Tübingen, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University of Tübingen, 72076 Tübingen, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University of Tübingen, 72076 Tübingen, GermanyDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Tübingen, Eberhard Karls University of Tübingen, 72076 Tübingen, GermanyDaptomycin is a cyclic lipopeptide antibiotic with bactericidal effects against multidrug-resistant Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). For critically ill patients, especially in the presence of implants, daptomycin is an important therapeutic option. Left ventricle assist devices (LVADs) can be utilized for intensive care patients with end-stage heart failure as a bridge to transplant. We conducted a single-center prospective trial with critically ill adults with LVAD who received prophylactic anti-infective therapy with daptomycin. Our study aimed to evaluate the pharmacokinetics of daptomycin in the blood serum and wound fluids after LVAD implantation. Daptomycin concentration were assessed over three days using high-performance liquid chromatography (HPLC). We detected a high correlation between blood serum and wound fluid daptomycin concentration at 12 h (IC95%: 0.64 to 0.95; r = 0.86; <i>p</i> < 0.001) and 24 h (IC95%: −0.38 to 0.92; r = 0.76; <i>p</i> < 0.001) after antibiotic administration. Our pilot clinical study provides new insights into the pharmacokinetics of daptomycin from the blood into wound fluids of critically ill patients with LVADs.https://www.mdpi.com/2079-6382/12/5/904daptomycincyclic lipopeptide antibioticleft ventricle assist devicetherapeutic drug monitoring |
| spellingShingle | Stefanie Calov Frederik Munzel Anka C. Roehr Otto Frey Lina Maria Serna Higuita Petra Wied Peter Rosenberger Helene A. Haeberle Kristian-Christos Ngamsri Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices Antibiotics daptomycin cyclic lipopeptide antibiotic left ventricle assist device therapeutic drug monitoring |
| title | Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices |
| title_full | Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices |
| title_fullStr | Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices |
| title_full_unstemmed | Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices |
| title_short | Daptomycin Pharmacokinetics in Blood and Wound Fluid in Critical Ill Patients with Left Ventricle Assist Devices |
| title_sort | daptomycin pharmacokinetics in blood and wound fluid in critical ill patients with left ventricle assist devices |
| topic | daptomycin cyclic lipopeptide antibiotic left ventricle assist device therapeutic drug monitoring |
| url | https://www.mdpi.com/2079-6382/12/5/904 |
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