Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach
ABSTRACTThe gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often not well understood, particularly when targeting the sm...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2232506 |
| _version_ | 1827303751698874368 |
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| author | Jack Jansma Nicola U. Thome Markus Schwalbe Anastasia Chrysovalantou Chatziioannou Somayah S. Elsayed Gilles P. van Wezel Pieter van den Abbeele Saskia van Hemert Sahar El Aidy |
| author_facet | Jack Jansma Nicola U. Thome Markus Schwalbe Anastasia Chrysovalantou Chatziioannou Somayah S. Elsayed Gilles P. van Wezel Pieter van den Abbeele Saskia van Hemert Sahar El Aidy |
| author_sort | Jack Jansma |
| collection | DOAJ |
| description | ABSTRACTThe gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often not well understood, particularly when targeting the small intestinal microbiota. In this study, we investigated the effects of a probiotic formula (Ecologic®825) on the adult human small intestinal ileostoma microbiota. The results showed that supplementation with the probiotic formula led to a reduction in the growth of pathobionts, such as Enterococcaceae and Enterobacteriaceae, and a decrease in ethanol production. These changes were associated with significant alterations in nutrient utilization and resistance to perturbations. These probiotic mediated alterations which coincided with an initial increase in lactate production and decrease in pH were followed by a sharp increase in the levels of butyrate and propionate. Moreover, the probiotic formula increased the production of multiple N-acyl amino acids in the stoma samples. The study demonstrates the utility of network theory in identifying novel microbiota-targeted therapies and improving existing ones. Overall, the findings provide insights into the dynamic molecular mechanisms underlying probiotic therapies, which can aid in the development of more effective treatments for a range of conditions. |
| first_indexed | 2024-03-11T14:20:39Z |
| format | Article |
| id | doaj.art-aefc9eaf089d4395beb16aea36d020a3 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:36Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-aefc9eaf089d4395beb16aea36d020a32024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2232506Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approachJack Jansma0Nicola U. Thome1Markus Schwalbe2Anastasia Chrysovalantou Chatziioannou3Somayah S. Elsayed4Gilles P. van Wezel5Pieter van den Abbeele6Saskia van Hemert7Sahar El Aidy8Host-Microbe Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, The NetherlandsDepartment of Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The NetherlandsHost-Microbe Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, The NetherlandsHost-Microbe Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, The NetherlandsDepartment of Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The NetherlandsDepartment of Molecular Biotechnology, Institute of Biology, Leiden University, Leiden, The NetherlandsCryptobiotix SA, Ghent, BelgiumWinclove Probiotics, Amsterdam, The NetherlandsHost-Microbe Interactions, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, Groningen, The NetherlandsABSTRACTThe gut microbiota plays a pivotal role in health and disease. The use of probiotics as microbiota-targeted therapies is a promising strategy to improve host health. However, the molecular mechanisms involved in such therapies are often not well understood, particularly when targeting the small intestinal microbiota. In this study, we investigated the effects of a probiotic formula (Ecologic®825) on the adult human small intestinal ileostoma microbiota. The results showed that supplementation with the probiotic formula led to a reduction in the growth of pathobionts, such as Enterococcaceae and Enterobacteriaceae, and a decrease in ethanol production. These changes were associated with significant alterations in nutrient utilization and resistance to perturbations. These probiotic mediated alterations which coincided with an initial increase in lactate production and decrease in pH were followed by a sharp increase in the levels of butyrate and propionate. Moreover, the probiotic formula increased the production of multiple N-acyl amino acids in the stoma samples. The study demonstrates the utility of network theory in identifying novel microbiota-targeted therapies and improving existing ones. Overall, the findings provide insights into the dynamic molecular mechanisms underlying probiotic therapies, which can aid in the development of more effective treatments for a range of conditions.https://www.tandfonline.com/doi/10.1080/19490976.2023.2232506Probioticsgut microbiotasmall intestinedynamic correlation-based networksmetabolitessequencing |
| spellingShingle | Jack Jansma Nicola U. Thome Markus Schwalbe Anastasia Chrysovalantou Chatziioannou Somayah S. Elsayed Gilles P. van Wezel Pieter van den Abbeele Saskia van Hemert Sahar El Aidy Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach Gut Microbes Probiotics gut microbiota small intestine dynamic correlation-based networks metabolites sequencing |
| title | Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach |
| title_full | Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach |
| title_fullStr | Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach |
| title_full_unstemmed | Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach |
| title_short | Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach |
| title_sort | dynamic effects of probiotic formula ecologic r 825 on human small intestinal ileostoma microbiota a network theory approach |
| topic | Probiotics gut microbiota small intestine dynamic correlation-based networks metabolites sequencing |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2232506 |
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