Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects?
The reason why metabolic rate often scales allometrically (disproportionately) with body mass has been debated for decades. A critical question concerns whether metabolic scaling is controlled intrinsically at the intracellular level or systemically at the organismal level. Recently, the relative im...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-03-01
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| Series: | Biology |
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| Online Access: | http://www.mdpi.com/2079-7737/4/1/187 |
| _version_ | 1797761597079289856 |
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| author | Douglas S. Glazier |
| author_facet | Douglas S. Glazier |
| author_sort | Douglas S. Glazier |
| collection | DOAJ |
| description | The reason why metabolic rate often scales allometrically (disproportionately) with body mass has been debated for decades. A critical question concerns whether metabolic scaling is controlled intrinsically at the intracellular level or systemically at the organismal level. Recently, the relative importance of these effects has been tested by examining the metabolic rates of cultured dermal fibroblast and skeletal muscle cells in relation to donor body mass of a variety of birds and mammals. The lack of a relationship between in vitro cellular metabolic rates and body mass suggests that systemic effects, not intrinsic cellular effects are responsible for allometric metabolic scaling observed in whole organisms. Influential resource-transport network theory claims that the most important systemic effect involved is body-size related resource-supply limits to metabolizing cells. However, comparisons of in vitro cellular metabolic rates with scaling relationships for in vivo (basal) metabolic rates suggest that other systemic effects, such as body-size dependent biological regulation and tissue composition may also have major, perhaps more important effects. Furthermore, systemic effects must ultimately act at the cellular level, for example, by induced variation in the function, structure and intracellular densities of mitochondria. The mechanistic pathways involved require further study. |
| first_indexed | 2024-03-12T19:15:43Z |
| format | Article |
| id | doaj.art-aefdd700f54f47d7bea7897ba15fc45b |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T19:15:43Z |
| publishDate | 2015-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-aefdd700f54f47d7bea7897ba15fc45b2023-08-02T05:33:10ZengMDPI AGBiology2079-77372015-03-014118719910.3390/biology4010187biology4010187Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects?Douglas S. Glazier0Department of Biology, Juniata College, Huntingdon, PA 16652, USAThe reason why metabolic rate often scales allometrically (disproportionately) with body mass has been debated for decades. A critical question concerns whether metabolic scaling is controlled intrinsically at the intracellular level or systemically at the organismal level. Recently, the relative importance of these effects has been tested by examining the metabolic rates of cultured dermal fibroblast and skeletal muscle cells in relation to donor body mass of a variety of birds and mammals. The lack of a relationship between in vitro cellular metabolic rates and body mass suggests that systemic effects, not intrinsic cellular effects are responsible for allometric metabolic scaling observed in whole organisms. Influential resource-transport network theory claims that the most important systemic effect involved is body-size related resource-supply limits to metabolizing cells. However, comparisons of in vitro cellular metabolic rates with scaling relationships for in vivo (basal) metabolic rates suggest that other systemic effects, such as body-size dependent biological regulation and tissue composition may also have major, perhaps more important effects. Furthermore, systemic effects must ultimately act at the cellular level, for example, by induced variation in the function, structure and intracellular densities of mitochondria. The mechanistic pathways involved require further study.http://www.mdpi.com/2079-7737/4/1/187biological regulationbody masscellular metabolic ratemitochondriascalingresource-supply limitssystemic effectstissue composition |
| spellingShingle | Douglas S. Glazier Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects? Biology biological regulation body mass cellular metabolic rate mitochondria scaling resource-supply limits systemic effects tissue composition |
| title | Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects? |
| title_full | Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects? |
| title_fullStr | Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects? |
| title_full_unstemmed | Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects? |
| title_short | Body-Mass Scaling of Metabolic Rate: What are the Relative Roles of Cellular versus Systemic Effects? |
| title_sort | body mass scaling of metabolic rate what are the relative roles of cellular versus systemic effects |
| topic | biological regulation body mass cellular metabolic rate mitochondria scaling resource-supply limits systemic effects tissue composition |
| url | http://www.mdpi.com/2079-7737/4/1/187 |
| work_keys_str_mv | AT douglassglazier bodymassscalingofmetabolicratewhataretherelativerolesofcellularversussystemiceffects |