Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection

Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection

Lipoproteins are able to neutralize bacterial lipopolysaccharide (LPS) and thereby inhibit the proinflammatory cytokine response. In a previous study, we demonstrated that hypercholesterolemic low density lipoprotein receptor knock-out (LDLr–/–) mice are protected against lethal endotoxemia and gram...

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Bibliographic Details
Main Authors: Natasja de Bont, Mihai G. Netea, Pierre N.M. Demacker, Ineke Verschueren, Bart Jan Kullberg, Ko Willems van Dijk, Jos W.M. van der Meer, Anton F.H. Stalenhoef
Format: Article
Language:English
Published: Elsevier 1999-04-01
Series:Journal of Lipid Research
Subjects:
lipopolysaccharide
tumor necrosis factor
apolipoprotein E
hypercholesterolemia
neutralization
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520321477

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