Breathing patterns in people with exercise‐induced laryngeal obstruction
Abstract Exercise‐induced laryngeal obstruction (EILO) is common, but we lack readily available diagnostic tools. The larynx represents an important point of resistance in the airways, and we therefore hypothesized that EILO is associated with characteristic breathing patterns possible to record fro...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-11-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.15086 |
| _version_ | 1818993051878555648 |
|---|---|
| author | Astrid Haugen Lie Ingvild Grønnevik Bente Frisk Ola Drange Røksund Ida Hammer Maria Vollsæter Thomas Halvorsen Hege H. Clemm |
| author_facet | Astrid Haugen Lie Ingvild Grønnevik Bente Frisk Ola Drange Røksund Ida Hammer Maria Vollsæter Thomas Halvorsen Hege H. Clemm |
| author_sort | Astrid Haugen Lie |
| collection | DOAJ |
| description | Abstract Exercise‐induced laryngeal obstruction (EILO) is common, but we lack readily available diagnostic tools. The larynx represents an important point of resistance in the airways, and we therefore hypothesized that EILO is associated with characteristic breathing patterns possible to record from a standard incremental ergospirometry test. We studied 24 individuals with moderate/severe EILO and 20 individuals with no‐EILO, mean (SD) age 17 (6.1) and 24 (6.4) years, respectively. EILO versus no‐EILO was verified from maximal continuous laryngoscopy treadmill exercise (CLE) tests, which also included ergospirometry. We described the relationships between minute ventilation (V˙E) versus tidal volume (VT) and V˙E versus carbon dioxide output (V˙CO2), using respectively quadratic and linear equations, and applied adjusted regression models to compare ergospirometry data and curve parameters. Compared to the no‐EILO group, the group with EILO had prolonged inspiratory time (Tin), lower breathing frequency (Bf), lower V˙E, and lower inspiratory flow rate (V˙in) at peak exercise. Mathematical modeling of the breathing pattern relationships was feasible in both groups, with similar coefficients of variation. For V˙E versus VT, the mathematical curve parameters were similar. For V˙E versus V˙CO2, the slope was similar but the intercept was lower in the EILO group. EILO was associated with prolonged Tin, lower Bf, V˙E, and V˙E. The relationship between V˙E versus VT was similar, whereas for V˙E versus V˙CO2, the slope was almost parallel but shifted downward for the EILO group. Most ergospirometry data overlapped, except V˙in which discriminated between EILO and no‐EILO in a promising way. |
| first_indexed | 2024-12-20T20:35:55Z |
| format | Article |
| id | doaj.art-af000f98094041899c71c717980eedb9 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-20T20:35:55Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-af000f98094041899c71c717980eedb92022-12-21T19:27:14ZengWileyPhysiological Reports2051-817X2021-11-01922n/an/a10.14814/phy2.15086Breathing patterns in people with exercise‐induced laryngeal obstructionAstrid Haugen Lie0Ingvild Grønnevik1Bente Frisk2Ola Drange Røksund3Ida Hammer4Maria Vollsæter5Thomas Halvorsen6Hege H. Clemm7Department of Clinical Science University of Bergen Bergen NorwayDepartment of Clinical Science University of Bergen Bergen NorwayDepartment of Health and Functioning Western Norway University of Applied Sciences Bergen NorwayDepartment of Health and Functioning Western Norway University of Applied Sciences Bergen NorwayDepartment of Pediatric and Adolescent Medicine Haukeland University Hospital Bergen NorwayDepartment of Clinical Science University of Bergen Bergen NorwayDepartment of Clinical Science University of Bergen Bergen NorwayDepartment of Clinical Science University of Bergen Bergen NorwayAbstract Exercise‐induced laryngeal obstruction (EILO) is common, but we lack readily available diagnostic tools. The larynx represents an important point of resistance in the airways, and we therefore hypothesized that EILO is associated with characteristic breathing patterns possible to record from a standard incremental ergospirometry test. We studied 24 individuals with moderate/severe EILO and 20 individuals with no‐EILO, mean (SD) age 17 (6.1) and 24 (6.4) years, respectively. EILO versus no‐EILO was verified from maximal continuous laryngoscopy treadmill exercise (CLE) tests, which also included ergospirometry. We described the relationships between minute ventilation (V˙E) versus tidal volume (VT) and V˙E versus carbon dioxide output (V˙CO2), using respectively quadratic and linear equations, and applied adjusted regression models to compare ergospirometry data and curve parameters. Compared to the no‐EILO group, the group with EILO had prolonged inspiratory time (Tin), lower breathing frequency (Bf), lower V˙E, and lower inspiratory flow rate (V˙in) at peak exercise. Mathematical modeling of the breathing pattern relationships was feasible in both groups, with similar coefficients of variation. For V˙E versus VT, the mathematical curve parameters were similar. For V˙E versus V˙CO2, the slope was similar but the intercept was lower in the EILO group. EILO was associated with prolonged Tin, lower Bf, V˙E, and V˙E. The relationship between V˙E versus VT was similar, whereas for V˙E versus V˙CO2, the slope was almost parallel but shifted downward for the EILO group. Most ergospirometry data overlapped, except V˙in which discriminated between EILO and no‐EILO in a promising way.https://doi.org/10.14814/phy2.15086EILOexercise physiologylaryngeal obstructionrespiratory physiology |
| spellingShingle | Astrid Haugen Lie Ingvild Grønnevik Bente Frisk Ola Drange Røksund Ida Hammer Maria Vollsæter Thomas Halvorsen Hege H. Clemm Breathing patterns in people with exercise‐induced laryngeal obstruction Physiological Reports EILO exercise physiology laryngeal obstruction respiratory physiology |
| title | Breathing patterns in people with exercise‐induced laryngeal obstruction |
| title_full | Breathing patterns in people with exercise‐induced laryngeal obstruction |
| title_fullStr | Breathing patterns in people with exercise‐induced laryngeal obstruction |
| title_full_unstemmed | Breathing patterns in people with exercise‐induced laryngeal obstruction |
| title_short | Breathing patterns in people with exercise‐induced laryngeal obstruction |
| title_sort | breathing patterns in people with exercise induced laryngeal obstruction |
| topic | EILO exercise physiology laryngeal obstruction respiratory physiology |
| url | https://doi.org/10.14814/phy2.15086 |
| work_keys_str_mv | AT astridhaugenlie breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction AT ingvildgrønnevik breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction AT bentefrisk breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction AT oladrangerøksund breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction AT idahammer breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction AT mariavollsæter breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction AT thomashalvorsen breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction AT hegehclemm breathingpatternsinpeoplewithexerciseinducedlaryngealobstruction |