The effects of UV light on the antimicrobial activities of cave actinomycetes
The goal of this study was to determine whether actinomycetes isolated from a volcanic cave in western Canada could produce novel antimicrobial compounds against six multidrug- resistant pathogens when exposed to UV light. One hundred and seventy-six actinomycete strains isolated from Helmcken Falls...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
University of South Florida Libraries
2013-07-01
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| Series: | International Journal of Speleology |
| Subjects: | |
| Online Access: | http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=1739&context=ijs |
| _version_ | 1819296678949158912 |
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| author | Rule Devon Naowarat Cheeptham |
| author_facet | Rule Devon Naowarat Cheeptham |
| author_sort | Rule Devon |
| collection | DOAJ |
| description | The goal of this study was to determine whether actinomycetes isolated from a volcanic cave in western Canada could produce novel antimicrobial compounds against six multidrug- resistant pathogens when exposed to UV light. One hundred and seventy-six actinomycete strains isolated from Helmcken Falls Cave, Wells Gray Provincial Park, BC, were screened against six pathogens using the “plug assay” in UV light and no light conditions. Of the 176 strains tested, 100 or 57% of the cave actinomycete strains had antimicrobial activities against the pathogens in 124 different instances: 35 instances when exposed to UV and no light, 30 when exposed to UV light, and 59 instances when exposed to no light. The metabolites of six actinomycete strains also lost their antimicrobial activities when exposed to UV light. While the metabolites produced by these strains have yet to be determined, exposure to lighted environments may either deactivate or enhance the antimicrobial activities of cave actinomycete strains. This study represents a confirmation that cave actinomycetes are potential sources of novel antimicrobial compounds and also is the first report of the enhancement of antimicrobial activities of some cave bacteria by exposure to UV light. Further investigation of the role of UV light with respect to activation/deactivation of antimicrobial activities of cave actinomycetes is required. |
| first_indexed | 2024-12-24T05:01:56Z |
| format | Article |
| id | doaj.art-af00a74df2624cc6abb1442b59fecd6c |
| institution | Directory Open Access Journal |
| issn | 0392-6672 1827-806X |
| language | English |
| last_indexed | 2024-12-24T05:01:56Z |
| publishDate | 2013-07-01 |
| publisher | University of South Florida Libraries |
| record_format | Article |
| series | International Journal of Speleology |
| spelling | doaj.art-af00a74df2624cc6abb1442b59fecd6c2022-12-21T17:13:59ZengUniversity of South Florida LibrariesInternational Journal of Speleology0392-66721827-806X2013-07-01422147153http://dx.doi.org/10.5038/1827-806X.42.2.7The effects of UV light on the antimicrobial activities of cave actinomycetesRule DevonNaowarat CheepthamThe goal of this study was to determine whether actinomycetes isolated from a volcanic cave in western Canada could produce novel antimicrobial compounds against six multidrug- resistant pathogens when exposed to UV light. One hundred and seventy-six actinomycete strains isolated from Helmcken Falls Cave, Wells Gray Provincial Park, BC, were screened against six pathogens using the “plug assay” in UV light and no light conditions. Of the 176 strains tested, 100 or 57% of the cave actinomycete strains had antimicrobial activities against the pathogens in 124 different instances: 35 instances when exposed to UV and no light, 30 when exposed to UV light, and 59 instances when exposed to no light. The metabolites of six actinomycete strains also lost their antimicrobial activities when exposed to UV light. While the metabolites produced by these strains have yet to be determined, exposure to lighted environments may either deactivate or enhance the antimicrobial activities of cave actinomycete strains. This study represents a confirmation that cave actinomycetes are potential sources of novel antimicrobial compounds and also is the first report of the enhancement of antimicrobial activities of some cave bacteria by exposure to UV light. Further investigation of the role of UV light with respect to activation/deactivation of antimicrobial activities of cave actinomycetes is required.http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=1739&context=ijsvolcanic caveantimicrobial activitycave actinomycetesUV effectsmultidrug resistance pathogens |
| spellingShingle | Rule Devon Naowarat Cheeptham The effects of UV light on the antimicrobial activities of cave actinomycetes International Journal of Speleology volcanic cave antimicrobial activity cave actinomycetes UV effects multidrug resistance pathogens |
| title | The effects of UV light on the antimicrobial activities of cave actinomycetes |
| title_full | The effects of UV light on the antimicrobial activities of cave actinomycetes |
| title_fullStr | The effects of UV light on the antimicrobial activities of cave actinomycetes |
| title_full_unstemmed | The effects of UV light on the antimicrobial activities of cave actinomycetes |
| title_short | The effects of UV light on the antimicrobial activities of cave actinomycetes |
| title_sort | effects of uv light on the antimicrobial activities of cave actinomycetes |
| topic | volcanic cave antimicrobial activity cave actinomycetes UV effects multidrug resistance pathogens |
| url | http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=1739&context=ijs |
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