Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study
Backgrounds This study explored the contribution of peripheral blood markers in diagnosis and prognosis estimation of different stages of laryngeal dysplasia and early glottic cancer. Methods Retrospective analysis of clinical, histopathological and laboratory data of 220 patients including hemoglob...
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PeerJ Inc.
2023-09-01
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| Online Access: | https://peerj.com/articles/15642.pdf |
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| author | Anna Rzepakowska Wioletta Pietruszewska Michał Żurek Maria Molga-Magusiak Michał Leszczyński Kazimierz Niemczyk |
| author_facet | Anna Rzepakowska Wioletta Pietruszewska Michał Żurek Maria Molga-Magusiak Michał Leszczyński Kazimierz Niemczyk |
| author_sort | Anna Rzepakowska |
| collection | DOAJ |
| description | Backgrounds This study explored the contribution of peripheral blood markers in diagnosis and prognosis estimation of different stages of laryngeal dysplasia and early glottic cancer. Methods Retrospective analysis of clinical, histopathological and laboratory data of 220 patients including hemoglobin, neutrophil, lymphocyte, monocyte and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR). Results The mean hemoglobin level and platelets count showed differences between histopathological stages of lesions (p = 0.041 and 0.046, respectively). In patients with recurrent lesions mean level of lymphocyte count, NLR and PLR were significant in assessing progression and cancerization (p = 0.005, 0.028 and 0.023, respectively). The univariate analysis recognized level of PLR ≥ 141.74 as significant risk factor of the recurrence of vocal fold hypertrophic lesions (OR = 1.963). Conclusions The levels of blood cells and their ratios seem to be effective in predicting the recurrence of lesion and even more their potential role in indicating malignant progression. |
| first_indexed | 2024-03-09T08:08:52Z |
| format | Article |
| id | doaj.art-af00f49fec4547fa943f5cbed975ea87 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:08:52Z |
| publishDate | 2023-09-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
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| spelling | doaj.art-af00f49fec4547fa943f5cbed975ea872023-12-02T23:40:55ZengPeerJ Inc.PeerJ2167-83592023-09-0111e1564210.7717/peerj.15642Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective studyAnna Rzepakowska0Wioletta Pietruszewska1Michał Żurek2Maria Molga-Magusiak3Michał Leszczyński4Kazimierz Niemczyk5Department of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, PolandDepartment of Otiatrics, Laryngology and Laryngological Oncology, Medical University of Łódź, Łódź, PolandDepartment of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, PolandDepartment of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, PolandDepartment of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, PolandDepartment of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, PolandBackgrounds This study explored the contribution of peripheral blood markers in diagnosis and prognosis estimation of different stages of laryngeal dysplasia and early glottic cancer. Methods Retrospective analysis of clinical, histopathological and laboratory data of 220 patients including hemoglobin, neutrophil, lymphocyte, monocyte and platelet counts, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR). Results The mean hemoglobin level and platelets count showed differences between histopathological stages of lesions (p = 0.041 and 0.046, respectively). In patients with recurrent lesions mean level of lymphocyte count, NLR and PLR were significant in assessing progression and cancerization (p = 0.005, 0.028 and 0.023, respectively). The univariate analysis recognized level of PLR ≥ 141.74 as significant risk factor of the recurrence of vocal fold hypertrophic lesions (OR = 1.963). Conclusions The levels of blood cells and their ratios seem to be effective in predicting the recurrence of lesion and even more their potential role in indicating malignant progression.https://peerj.com/articles/15642.pdfLaryngeal cancerLaryngeal dysplasiaLymphocyte countNeutrophil countNeutrophil to lymphocyte ratioBlood markers |
| spellingShingle | Anna Rzepakowska Wioletta Pietruszewska Michał Żurek Maria Molga-Magusiak Michał Leszczyński Kazimierz Niemczyk Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study PeerJ Laryngeal cancer Laryngeal dysplasia Lymphocyte count Neutrophil count Neutrophil to lymphocyte ratio Blood markers |
| title | Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study |
| title_full | Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study |
| title_fullStr | Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study |
| title_full_unstemmed | Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study |
| title_short | Preoperative lymphocyte count, neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions—retrospective study |
| title_sort | preoperative lymphocyte count neutrophil to lymphocyte and platelet to lymphocyte ratio predict the recurrence with progression and cancerization in vocal fold lesions retrospective study |
| topic | Laryngeal cancer Laryngeal dysplasia Lymphocyte count Neutrophil count Neutrophil to lymphocyte ratio Blood markers |
| url | https://peerj.com/articles/15642.pdf |
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