Characterization of Endoplasmic Reticulum (ER) in Human Pluripotent Stem Cells Revealed Increased Susceptibility to Cell Death upon ER Stress

Characterization of Endoplasmic Reticulum (ER) in Human Pluripotent Stem Cells Revealed Increased Susceptibility to Cell Death upon ER Stress

Human pluripotent stem cells (hPSCs), such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have a well-orchestrated program for differentiation and self-renewal. However, the structural features of unique proteostatic-maintaining mechanisms in hPSCs and their features, dis...

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Bibliographic Details
Main Authors: Tae Won Ha, Ji Hun Jeong, HyeonSeok Shin, Hyun Kyu Kim, Jeong Suk Im, Byung Hoo Song, Jacob Hanna, Jae Sang Oh, Dong-Hun Woo, Jaeseok Han, Man Ryul Lee
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
human pluripotent stem cells
endoplasmic reticulum (ER)
ER stress
binding immunoglobulin protein (BiP)
C/EBP homologous protein (CHOP)
proteostasis
Online Access:https://www.mdpi.com/2073-4409/9/5/1078

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https://www.mdpi.com/2073-4409/9/5/1078

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