Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex
It is considered that brain ischemia can be causative connected to Alzheimer’s disease. In the CA1 and CA3 regions of the hippocampus and temporal cortex, genes related to Alzheimer’s disease, such as the <i>amyloid protein precursor (APP)</i>, <i>β-secretase</i> (<i>BA...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/6/1059 |
| _version_ | 1797487093445820416 |
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| author | Ryszard Pluta |
| author_facet | Ryszard Pluta |
| author_sort | Ryszard Pluta |
| collection | DOAJ |
| description | It is considered that brain ischemia can be causative connected to Alzheimer’s disease. In the CA1 and CA3 regions of the hippocampus and temporal cortex, genes related to Alzheimer’s disease, such as the <i>amyloid protein precursor (APP)</i>, <i>β-secretase</i> (<i>BACE1</i>), <i>presenilin 1</i> (<i>PSEN1</i>) and <i>2</i> (<i>PSEN2</i>), are deregulated by ischemia. The pattern of change in the CA1 area of the hippocampus covers all genes tested, and the changes occur at all post-ischemic times. In contrast, the pattern of gene changes in the CA3 subfield is much less intense, does not occur at all post-ischemic times, and is delayed in time post-ischemia relative to the CA1 field. Conversely, the pattern of gene alterations in the temporal cortex appears immediately after ischemia, and does not occur at all post-ischemic times and does not affect all genes. Evidence therefore suggests that various forms of dysregulation of the <i>APP</i>, <i>BACE1</i> and <i>PSEN1 and PSEN2</i> genes are associated with individual neuronal cell responses in the CA1 and CA3 areas of the hippocampus and temporal cortex with reversible cerebral ischemia. Scientific data indicate that an ischemic episode of the brain is a trigger of amyloidogenic processes. From the information provided, it appears that post-ischemic brain injury additionally activates neuronal death in the hippocampus and temporal cortex in an amyloid-dependent manner. |
| first_indexed | 2024-03-09T23:43:07Z |
| format | Article |
| id | doaj.art-af06a62607474f4c8747e8d5ca62383c |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T23:43:07Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-af06a62607474f4c8747e8d5ca62383c2023-11-23T16:48:36ZengMDPI AGGenes2073-44252022-06-01136105910.3390/genes13061059Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal CortexRyszard Pluta0Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandIt is considered that brain ischemia can be causative connected to Alzheimer’s disease. In the CA1 and CA3 regions of the hippocampus and temporal cortex, genes related to Alzheimer’s disease, such as the <i>amyloid protein precursor (APP)</i>, <i>β-secretase</i> (<i>BACE1</i>), <i>presenilin 1</i> (<i>PSEN1</i>) and <i>2</i> (<i>PSEN2</i>), are deregulated by ischemia. The pattern of change in the CA1 area of the hippocampus covers all genes tested, and the changes occur at all post-ischemic times. In contrast, the pattern of gene changes in the CA3 subfield is much less intense, does not occur at all post-ischemic times, and is delayed in time post-ischemia relative to the CA1 field. Conversely, the pattern of gene alterations in the temporal cortex appears immediately after ischemia, and does not occur at all post-ischemic times and does not affect all genes. Evidence therefore suggests that various forms of dysregulation of the <i>APP</i>, <i>BACE1</i> and <i>PSEN1 and PSEN2</i> genes are associated with individual neuronal cell responses in the CA1 and CA3 areas of the hippocampus and temporal cortex with reversible cerebral ischemia. Scientific data indicate that an ischemic episode of the brain is a trigger of amyloidogenic processes. From the information provided, it appears that post-ischemic brain injury additionally activates neuronal death in the hippocampus and temporal cortex in an amyloid-dependent manner.https://www.mdpi.com/2073-4425/13/6/1059brain ischemiahippocampustemporal cortexgenesAlzheimer’s disease<i>amyloid protein precursor</i> |
| spellingShingle | Ryszard Pluta Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex Genes brain ischemia hippocampus temporal cortex genes Alzheimer’s disease <i>amyloid protein precursor</i> |
| title | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
| title_full | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
| title_fullStr | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
| title_full_unstemmed | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
| title_short | Alzheimer’s Disease Connected Genes in the Post-Ischemic Hippocampus and Temporal Cortex |
| title_sort | alzheimer s disease connected genes in the post ischemic hippocampus and temporal cortex |
| topic | brain ischemia hippocampus temporal cortex genes Alzheimer’s disease <i>amyloid protein precursor</i> |
| url | https://www.mdpi.com/2073-4425/13/6/1059 |
| work_keys_str_mv | AT ryszardpluta alzheimersdiseaseconnectedgenesinthepostischemichippocampusandtemporalcortex |