ONECUT1 variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts

ONECUT1 variants beyond type 1 and type 2 diabetes: exploring clinical diversity and epigenetic associations in Arab cohorts

ONECUT1 gene, encoding hepatocyte nuclear factor 6, is involved in pancreas and liver development. ONECUT1 mutations impair the function of pancreatic β-cells and control a transcriptional/epigenetic machinery regulating endocrine development. Homozygous nonsense and missense mutations at ONECUT1_p....

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Bibliographic Details
Main Authors:	Mohammed Dashti, Rasheeba Nizam, Sumi Elsa John, Motasem Melhem, Arshad Channanath, Hessa Alkandari, Thangavel Alphonse Thanaraj, Fahd Al-Mulla
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Series:	Frontiers in Genetics
Subjects:	ONECUT1 SNP MODY T1D T2D Arab ethnicity
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1254833/full

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