Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans
Chronic itch can severely affect quality of life. Patients report that their chronic itch can be exacerbated by exposure to warm conditions (“warmth hyperknesis”). The aim of this mechanistic study was to investigate the effect of mild heating of the skin in humans on various experimental models of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2022-02-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/173 |
| _version_ | 1828882554500939776 |
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| author | Daniele Riccio Hjalte Holm Andersen Lars Arendt-Nielsen |
| author_facet | Daniele Riccio Hjalte Holm Andersen Lars Arendt-Nielsen |
| author_sort | Daniele Riccio |
| collection | DOAJ |
| description | Chronic itch can severely affect quality of life. Patients report that their chronic itch can be exacerbated by exposure to warm conditions (“warmth hyperknesis”). The aim of this mechanistic study was to investigate the effect of mild heating of the skin in humans on various experimental models of itch. A total of 18 healthy subjects were recruited to the study. Itch was provoked by histamine, serotonin, or cowhage in 3 different sessions. The provoked area was heated with an infrared lamp, and the skin temperature was either not altered, or was increased by 4°C or 7°C. Subsequent to induction of itch, the itch intensity was recorded for 10 min while the skin was heated continuously throughout the entire period of itch induction. Heating the skin resulted in a significant increase in itch intensity when provoked by histamine or serotonin. It is possible that thermoception and pruriception interact and selectively produce a higher itch intensity in histaminergic and serotoninergic itch.
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| first_indexed | 2024-12-13T10:30:33Z |
| format | Article |
| id | doaj.art-af085d13022c4b118461bdbd55829564 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-13T10:30:33Z |
| publishDate | 2022-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-af085d13022c4b118461bdbd558295642022-12-21T23:50:53ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572022-02-0110210.2340/actadv.v102.173Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in HumansDaniele Riccio0Hjalte Holm AndersenLars Arendt-Nielsen1Aalborg UniversityFaculty of Medicine, Aalborg University, Fredrik Bajers Vej, D3-212, DK-9220 Aalborg East, DenmarkChronic itch can severely affect quality of life. Patients report that their chronic itch can be exacerbated by exposure to warm conditions (“warmth hyperknesis”). The aim of this mechanistic study was to investigate the effect of mild heating of the skin in humans on various experimental models of itch. A total of 18 healthy subjects were recruited to the study. Itch was provoked by histamine, serotonin, or cowhage in 3 different sessions. The provoked area was heated with an infrared lamp, and the skin temperature was either not altered, or was increased by 4°C or 7°C. Subsequent to induction of itch, the itch intensity was recorded for 10 min while the skin was heated continuously throughout the entire period of itch induction. Heating the skin resulted in a significant increase in itch intensity when provoked by histamine or serotonin. It is possible that thermoception and pruriception interact and selectively produce a higher itch intensity in histaminergic and serotoninergic itch. https://medicaljournalssweden.se/actadv/article/view/173ItchWarmthHyperknesisHistamineSerotoninCowhage |
| spellingShingle | Daniele Riccio Hjalte Holm Andersen Lars Arendt-Nielsen Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans Acta Dermato-Venereologica Itch Warmth Hyperknesis Histamine Serotonin Cowhage |
| title | Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans |
| title_full | Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans |
| title_fullStr | Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans |
| title_full_unstemmed | Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans |
| title_short | Mild Skin Heating Evokes Warmth Hyperknesis Selectively for Histaminergic and Serotoninergic Itch in Humans |
| title_sort | mild skin heating evokes warmth hyperknesis selectively for histaminergic and serotoninergic itch in humans |
| topic | Itch Warmth Hyperknesis Histamine Serotonin Cowhage |
| url | https://medicaljournalssweden.se/actadv/article/view/173 |
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